Effects of Subanesthetic Concentrations of Isoflurane/Nitrous Oxide
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 10
- 试验地点
- 1
- 主要终点
- Logical reasoning test
研究概览
简要总结
The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used to assess reinforcing effects. To evaluate the acute and residual effects of subanesthetic concentrations of isoflurane/nitrous oxide combinations in healthy volunteers.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 21 Years 至 32 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- 未提供
研究组 & 干预措施
Placebo
Subjects inhale 100% oxygen
干预措施: 100% oxygen (Other)
30% N2O
Subjects inhale 30% N2O
干预措施: 30% N2O (Drug)
0.2% isoflurane
Subjects inhale 0.2% isoflurane
干预措施: 0.2% isoflurane (Drug)
0.4% isoflurane + 30% N2O
Subjects will inhale a combination of 0.4% isoflurane and 30% N2O
干预措施: 30% N2O (Drug)
0.4% isoflurane
Subjects inhale 0.4% isoflurane
干预措施: 0.4% isoflurane (Drug)
0.2% isoflurane + 30% N2O
Subjects will inhale a combination of 0.2% isoflurane and 30% N2O
干预措施: 30% N2O (Drug)
0.2% isoflurane + 30% N2O
Subjects will inhale a combination of 0.2% isoflurane and 30% N2O
干预措施: 0.2% isoflurane (Drug)
0.4% isoflurane + 30% N2O
Subjects will inhale a combination of 0.4% isoflurane and 30% N2O
干预措施: 0.4% isoflurane (Drug)
结局指标
主要结局
Logical reasoning test
时间窗: 15 & 30 min inhalation and 5, 30, & 60 min post inhalation
Free recall memory test
时间窗: 15 & 30 min inhalation and 5, 30, & 60 min post inhalation
Auditory reaction time
时间窗: 15 & 30 min inhalation and 5,30 & 60 min post inhalation
Digit symbol substitution test
时间窗: 2,15 & 30 min inhalation and 5,30 & 60 min post inhalation
次要结局
未报告次要终点