Effects of Subanesthetic Concentrations of Isoflurane/Nitrous Oxide
Overview
- Phase
- Phase 2
- Intervention
- 100% oxygen
- Conditions
- Opioid-Related Disorders
- Sponsor
- University of Chicago
- Enrollment
- 10
- Locations
- 1
- Primary Endpoint
- Logical reasoning test
- Status
- Completed
- Last Updated
- 10 years ago
Overview
Brief Summary
The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used to assess reinforcing effects. To evaluate the acute and residual effects of subanesthetic concentrations of isoflurane/nitrous oxide combinations in healthy volunteers.
Investigators
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- Not provided
Arms & Interventions
Placebo
Subjects inhale 100% oxygen
Intervention: 100% oxygen
30% N2O
Subjects inhale 30% N2O
Intervention: 30% N2O
0.2% isoflurane
Subjects inhale 0.2% isoflurane
Intervention: 0.2% isoflurane
0.4% isoflurane + 30% N2O
Subjects will inhale a combination of 0.4% isoflurane and 30% N2O
Intervention: 30% N2O
0.4% isoflurane
Subjects inhale 0.4% isoflurane
Intervention: 0.4% isoflurane
0.2% isoflurane + 30% N2O
Subjects will inhale a combination of 0.2% isoflurane and 30% N2O
Intervention: 30% N2O
0.2% isoflurane + 30% N2O
Subjects will inhale a combination of 0.2% isoflurane and 30% N2O
Intervention: 0.2% isoflurane
0.4% isoflurane + 30% N2O
Subjects will inhale a combination of 0.4% isoflurane and 30% N2O
Intervention: 0.4% isoflurane
Outcomes
Primary Outcomes
Logical reasoning test
Time Frame: 15 & 30 min inhalation and 5, 30, & 60 min post inhalation
Free recall memory test
Time Frame: 15 & 30 min inhalation and 5, 30, & 60 min post inhalation
Auditory reaction time
Time Frame: 15 & 30 min inhalation and 5,30 & 60 min post inhalation
Digit symbol substitution test
Time Frame: 2,15 & 30 min inhalation and 5,30 & 60 min post inhalation