Isoflurane at Subanesthetic Concentrations
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 10
- 试验地点
- 1
- 主要终点
- Pain response
研究概览
简要总结
The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used to assess reinforcing effects. To test the hypothesis that isoflurane at subanesthetic concentrations does not reduce cold-water immersion pain in healthy volunteers.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 21 Years 至 34 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- 未提供
研究组 & 干预措施
0% isoflurane
干预措施: 40% Nitrous oxide (Drug)
0% isoflurane
干预措施: Sham comparator (Other)
0.2% isoflurane
干预措施: 40% Nitrous oxide (Drug)
0.2% isoflurane
干预措施: 0.2% isoflurane (Drug)
0.4% isoflurane
干预措施: 40% Nitrous oxide (Drug)
0.4% isoflurane
干预措施: 0.4% isoflurane (Drug)
0.6% isoflurane
干预措施: 40% Nitrous oxide (Drug)
0.6% isoflurane
干预措施: 0.6% isoflurane (Drug)
结局指标
主要结局
Pain response
时间窗: Post inhalation
Effects of inhaled isoflurane on pain from immersion of subject's arm in ice cold water. Nitrous oxide (40%) was used as a positive control to confirm sensitivity of the pain assay.
次要结局
未报告次要终点