Isoflurane at Subanesthetic Concentrations
Overview
- Phase
- Phase 2
- Intervention
- 40% Nitrous oxide
- Conditions
- Opioid-Related Disorders
- Sponsor
- University of Chicago
- Enrollment
- 10
- Locations
- 1
- Primary Endpoint
- Pain response
- Status
- Completed
- Last Updated
- 10 years ago
Overview
Brief Summary
The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used to assess reinforcing effects. To test the hypothesis that isoflurane at subanesthetic concentrations does not reduce cold-water immersion pain in healthy volunteers.
Investigators
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- Not provided
Arms & Interventions
0% isoflurane
Intervention: 40% Nitrous oxide
0% isoflurane
Intervention: Sham comparator
0.2% isoflurane
Intervention: 40% Nitrous oxide
0.2% isoflurane
Intervention: 0.2% isoflurane
0.4% isoflurane
Intervention: 40% Nitrous oxide
0.4% isoflurane
Intervention: 0.4% isoflurane
0.6% isoflurane
Intervention: 40% Nitrous oxide
0.6% isoflurane
Intervention: 0.6% isoflurane
Outcomes
Primary Outcomes
Pain response
Time Frame: Post inhalation
Effects of inhaled isoflurane on pain from immersion of subject's arm in ice cold water. Nitrous oxide (40%) was used as a positive control to confirm sensitivity of the pain assay.