Role of Instructions in Nitrous Oxide Effects and Choice - 10

Not Applicable

Completed

• Conditions: Substance-Related Disorders; Opioid-Related Disorders
• Interventions: Drug: Nitrous oxide 10% & placebo; Drug: Nitrous oxide 20% & placebo; Drug: Nitrous oxide 30% & placebo; Drug: Nitrous oxide 40% and placebo

• Registration Number: NCT00000258
• Lead Sponsor: University of Chicago

Brief Summary

The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used to assess reinforcing effects. Comparisons between nitrous oxide, opiates, and benzodiazepine antagonists will be made. To evaluate the role of instructions in nitrous oxide subjective effects and choice.

Detailed Description

Not available

Study Timeline

• Study Start: 1996-04
• Primary Completion: 1997-11
• Study Completion: 1997-11
• Study First Submitted: 1999-09-20
• Study First Submitted QC: 1999-09-20
• Study First Posted: 1999-09-21
• Status Verified: 2015-05
• Last Update Submitted: 2015-05-26
• Last Update Posted: 2015-05-28

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 22

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Informed group	Nitrous oxide 10% & placebo	Group inhaled placebo and varying doses of nitrous oxide in pairs then chose which they wanted for a third inhalation.
Non-informed Group	Nitrous oxide 20% & placebo	Group and technician were blinded as to which gas they were inhaling in pairs with third inhalation subject's choice.
Informed group	Nitrous oxide 20% & placebo	Group inhaled placebo and varying doses of nitrous oxide in pairs then chose which they wanted for a third inhalation.
Non-informed Group	Nitrous oxide 10% & placebo	Group and technician were blinded as to which gas they were inhaling in pairs with third inhalation subject's choice.
Non-informed Group	Nitrous oxide 30% & placebo	Group and technician were blinded as to which gas they were inhaling in pairs with third inhalation subject's choice.
Non-informed Group	Nitrous oxide 40% and placebo	Group and technician were blinded as to which gas they were inhaling in pairs with third inhalation subject's choice.
Informed group	Nitrous oxide 30% & placebo	Group inhaled placebo and varying doses of nitrous oxide in pairs then chose which they wanted for a third inhalation.
Informed group	Nitrous oxide 40% and placebo	Group inhaled placebo and varying doses of nitrous oxide in pairs then chose which they wanted for a third inhalation.

Primary Outcome Measures

Name	Time	Method
Choice of nitrous oxide vs placebo	After 30 min inhalation of each	Subjects inhaled placebo and varying per centages of nitrous oxide in sampling pair, then chose for third inhalation. One group was told which of the gases they were inhaling during sampling and one group as well as the technician administering the inhalant was blinded. Psychomotor tests were done at each dose.

Trial Locations

Locations (1)

University of Chicago, Anesthesia & Critical Care; 🇺🇸 Chicago, Illinois, United States