Role of Instructions in Nitrous Oxide Effects and Choice
Overview
- Phase
- Not Applicable
- Intervention
- Nitrous oxide 10% & placebo
- Conditions
- Opioid-Related Disorders
- Sponsor
- University of Chicago
- Enrollment
- 22
- Locations
- 1
- Primary Endpoint
- Choice of nitrous oxide vs placebo
- Status
- Completed
- Last Updated
- 10 years ago
Overview
Brief Summary
The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used to assess reinforcing effects. Comparisons between nitrous oxide, opiates, and benzodiazepine antagonists will be made. To evaluate the role of instructions in nitrous oxide subjective effects and choice.
Investigators
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- Not provided
Arms & Interventions
Informed group
Group inhaled placebo and varying doses of nitrous oxide in pairs then chose which they wanted for a third inhalation.
Intervention: Nitrous oxide 10% & placebo
Informed group
Group inhaled placebo and varying doses of nitrous oxide in pairs then chose which they wanted for a third inhalation.
Intervention: Nitrous oxide 20% & placebo
Informed group
Group inhaled placebo and varying doses of nitrous oxide in pairs then chose which they wanted for a third inhalation.
Intervention: Nitrous oxide 30% & placebo
Informed group
Group inhaled placebo and varying doses of nitrous oxide in pairs then chose which they wanted for a third inhalation.
Intervention: Nitrous oxide 40% and placebo
Non-informed Group
Group and technician were blinded as to which gas they were inhaling in pairs with third inhalation subject's choice.
Intervention: Nitrous oxide 10% & placebo
Non-informed Group
Group and technician were blinded as to which gas they were inhaling in pairs with third inhalation subject's choice.
Intervention: Nitrous oxide 20% & placebo
Non-informed Group
Group and technician were blinded as to which gas they were inhaling in pairs with third inhalation subject's choice.
Intervention: Nitrous oxide 30% & placebo
Non-informed Group
Group and technician were blinded as to which gas they were inhaling in pairs with third inhalation subject's choice.
Intervention: Nitrous oxide 40% and placebo
Outcomes
Primary Outcomes
Choice of nitrous oxide vs placebo
Time Frame: After 30 min inhalation of each
Subjects inhaled placebo and varying per centages of nitrous oxide in sampling pair, then chose for third inhalation. One group was told which of the gases they were inhaling during sampling and one group as well as the technician administering the inhalant was blinded. Psychomotor tests were done at each dose.