Effects of Alcohol History on Effects of Nitrous Oxide - 9

Not Applicable

Completed

• Conditions: Alcohol-Related Disorders; Opioid-Related Disorders; Substance-Related Disorders
• Interventions: Drug: 0% N2O and 10% N2O; Drug: 0% N2O and 20% N2O; Drug: 0% N2O and 30% N2O; Drug: 0% N2O and 40% N2O

• Registration Number: NCT00000257
• Lead Sponsor: University of Chicago

Brief Summary

The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used to assess reinforcing effects. Comparisons between nitrous oxide, opiates, and benzodiazepine antagonists will be made. To determine effects of alcohol history on the reinforcing, subjective and psychomotor effects of nitrous oxide in healthy volunteers.

Detailed Description

Not available

Study Timeline

• Study Start: 1995-09
• Primary Completion: 1997-04
• Study Completion: 1997-04
• Study First Submitted: 1999-09-20
• Study First Submitted QC: 1999-09-20
• Study First Posted: 1999-09-21
• Status Verified: 2015-05
• Last Update Submitted: 2015-05-26
• Last Update Posted: 2015-05-28

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 19

Inclusion Criteria

Not provided

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Exclusion Criteria

Not provided

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Moderate drinkers	0% N2O and 40% N2O	-
Moderate drinkers	0% N2O and 20% N2O	-
Moderate drinkers	0% N2O and 30% N2O	-
Light drinkers	0% N2O and 20% N2O	-
Light drinkers	0% N2O and 30% N2O	-
Light drinkers	0% N2O and 40% N2O	-
Light drinkers	0% N2O and 10% N2O	-
Moderate drinkers	0% N2O and 10% N2O	-

Primary Outcome Measures

Name	Time	Method
Choice of nitrous oxide vs placebo	After 30 min inhalation each of N2O and placebo	Two subject groups (light drinkers vs moderate drinkers) were asked to inhale a given conc of N2O and inhale a placebo, then choose for a third inhalation. The subject \& the technician administering the inhalant were blinded. Testing was done at each dose.

Trial Locations

Locations (1)

University of Chicago, Anesthesia & Critical Care; 🇺🇸 Chicago, Illinois, United States