Effects of Alcohol History on Effects of Nitrous Oxide
Overview
- Phase
- Not Applicable
- Intervention
- 0% N2O and 10% N2O
- Conditions
- Alcohol-Related Disorders
- Sponsor
- University of Chicago
- Enrollment
- 19
- Locations
- 1
- Primary Endpoint
- Choice of nitrous oxide vs placebo
- Status
- Completed
- Last Updated
- 10 years ago
Overview
Brief Summary
The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used to assess reinforcing effects. Comparisons between nitrous oxide, opiates, and benzodiazepine antagonists will be made. To determine effects of alcohol history on the reinforcing, subjective and psychomotor effects of nitrous oxide in healthy volunteers.
Investigators
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- Not provided
Arms & Interventions
Light drinkers
Intervention: 0% N2O and 10% N2O
Light drinkers
Intervention: 0% N2O and 20% N2O
Light drinkers
Intervention: 0% N2O and 30% N2O
Light drinkers
Intervention: 0% N2O and 40% N2O
Moderate drinkers
Intervention: 0% N2O and 10% N2O
Moderate drinkers
Intervention: 0% N2O and 20% N2O
Moderate drinkers
Intervention: 0% N2O and 30% N2O
Moderate drinkers
Intervention: 0% N2O and 40% N2O
Outcomes
Primary Outcomes
Choice of nitrous oxide vs placebo
Time Frame: After 30 min inhalation each of N2O and placebo
Two subject groups (light drinkers vs moderate drinkers) were asked to inhale a given conc of N2O and inhale a placebo, then choose for a third inhalation. The subject \& the technician administering the inhalant were blinded. Testing was done at each dose.