Study of Inflammatory and Physiological Profiles of Healthy and Diseased Lung
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 230
- 试验地点
- 2
- 主要终点
- Blood samples for presence of airway disease immune endotypes
研究概览
简要总结
There are over 700,000 UK hospital admissions every year with lung disease symptoms. Two of the most common lung diseases contributing to these numbers are asthma and chronic obstructive pulmonary disease (COPD). The immunopathology of these diseases is not fully understood. Matched samples from the respiratory tract and circulation will be used to identify immune patterns throughout the respiratory system to elucidate the immunopathology of airway disease.
详细描述
In this observational study, we will be enrolling patients with diagnosed or suspected airways disease who are over 18 years old, as well as age matched healthy volunteers with no significant illness. Participants will be asked if they consent to enter the study, invited at clinically relevant time points (treatment change, disease exacerbation etc.) and to optional bronchoscopy visits. It is expected that participants will be seen yearly with any additional exacerbation/treatment visits also recorded. Research visits will occur at King's College London and the Guys and St Thomas' NHS Foundation Trust (GSTFT), with all bronchoscopy visits occurring within GSTFT
- Disease specific questionnaires.
- Lung function tests including spirometry or oscillometry (if not performed previously within 6 months)
- Sputum collection
- Nasal sampling including nasosorption, nasal brushing, nasal lavage, or nasopharyngeal swabs
- Exhaled breath
- Blood samples (<6 tablespoons)
Optional 7. Bronchoscopy involving a flexible fibreoptic camera passed into the lungs to collect bronchoalveolar lavage, bronchosorption, bronchial brushings and bronchial biopsies. 8. To repeat these procedures at later time - expected once per year or at times of clinically relevant changes
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Participant is willing and able to give informed consent for participation in the study
- •Aged 18 years or above
- •Patient: known or suspected airway disease
- •Healthy volunteer: considered to be in good health with no significant comorbidity (immune disorder, cancer etc.)
排除标准
- •Known or suspected current pulmonary tuberculosis, HIV (human immunodeficiency virus), Hepatitis B Virus, Hepatitis C Virus.
- •Surgery within the preceding 6 weeks
- •Participants who are pregnant
- •History of psychiatric, medical, or surgical disorders that in the opinion of the chief investigator may interfere with sample collection, undergo a bronchoscopy, or may compromise study completion or data collection
- •Alcohol or recreational drug abuse
- •Diagnosis of immunodeficiency requiring treatment
- •Unable to provide written informed consent
- •Unable to read or write English
- •Be considered, in the opinion of the investigator, to be an unsuitable candidate for the study
结局指标
主要结局
Blood samples for presence of airway disease immune endotypes
时间窗: 6 years
Blood samples taken to assess inflammatory mediators to determine airway disease severity. Physiological and inflammatory characterisation of participants with known or suspected airway disease at stable state, compared to healthy volunteers with the aim to identify distinct immune endotypes in airways disease
次要结局
- Blood samples for stability of airway disease immune endotypes(6 years)