Effect of Fully Blocking Type 1 Angiotensin Receptor on Blood Pressure, Cardiac Structure, Cardiac Function and Cognitive Function in Postmenopausal Hypertensive Women
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 102
- 主要终点
- Relative indexes of myocardial remodeling
研究概览
简要总结
This study compared the improvements of blood pressure levels, left ventricular hypertrophy, left ventricular diastolic function, vascular function and cognitive function between postmenopausal hypertensive women and age-matched hypertensive male patients through the evaluation of the effects of fully blocked AT1 receptor by valsartan. Additionally, the differences of the above indexes between the patients who were fully blocked AT1 receptor by valsartan and the patients who were treated with a single dose of valsartan treatment were assessed, so as to provide theory basis for clinical treatment of postmenopausal hypertensive women.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 40 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Clinical diagnosis of hypertension
- •Women are all postmenopausal
- •Must provide written informed consent
排除标准
- •Secondary hypertension
- •Coronary disease
- •Heart failure
- •Arterial fibrillation
- •Previous myocardial infarction
- •Previous stroke
- •Malignant disease
- •Kidney failure
- •Liver failure
- •Neoplastic disease
- •Severe neurological diseases
- •Severe metabolic or organic decompensation
- •Refuse to sign the informed consent form
研究组 & 干预措施
postmenopausal hypertensive women
干预措施: Valsartan 1 (Drug)
postmenopausal hypertensive women
干预措施: Valsartan 80 mg (Drug)
age-matched hypertensive male patients
干预措施: Valsartan 1 (Drug)
结局指标
主要结局
Relative indexes of myocardial remodeling
时间窗: Change from Baseline left ventricular mass index at 12 months.
Cardiac structure (left ventricular mass index in grams for square meter) measurement.
Ambulatory blood pressure monitoring
时间窗: Change from Baseline ABPM at 12 months.
Non-invasive ambulatory blood pressure monitoring (ABPM) was performed for every enrolled patient with an ABPM equipment.
Sexual hormones
时间窗: Baseline sexual hormones.
Blood samples used to analyze the levels of sexual hormones were collected between morning 8:00 and 9:00 after an overnight fast. The sexual hormones which include prolactin (PRL) and progesterone (P) units on nanogram per millilitre, luteinizing hormone (LH) and follicle-stimulating hormone (FSH) units on millionInternationalUnits per millilitre, testosterone (T) in nanogram per deciliter, estradiol (E2) in picogram per millilitre.
次要结局
未报告次要终点
研究者
Jing Yu
Principal Investigator
LanZhou University