NL-OMON26189尚未招募不适用
Evaluating retinal blood flow autoregulation by means of Optical Coherence Tomography (OCT-A)
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 125
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
入选标准
- •Any individual between 50 and 65 years old with healthy eyes (only mild refractive abnormalities corrected with glasses are allowed) and good overall health condition, having signed the consent form, and fitting the descriptions:
- •- Group #1: Symptomatic low blood pressure individuals
- •Defined as having at least one of: systolic blood pressure below 90 mmHg or diastolic blood pressure below 55 mmHg (without the use of any antihypertensive treatment), and at least one of (Appendix F1c):
- •a) migraine:
- •Migraine is defined as already diagnosed, or a score of 4 or 5 in the corresponding section of the questionnaire, according to the Migraine Screening Questionnaire (Positive Predictive Value: 95%, Negative Predictive Value: 94%).14
- •b) orthostatic hypotension:
- •Orthostatic hypotension is defined as already diagnosed, or a sustained reduction of systolic blood pressure (SBP) of at least 20 mmHg or diastolic blood pressure (DBP) of 10 mmHg within 3 minutes of standing.15
- •c) cold intolerance:
- •Cold intolerance is defined as a score of 30 or more in the corresponding section of the questionnaire.16
- •- Group #2: Asymptomatic low blood pressure individuals
- •Defined as having at least one of: systolic blood pressure below 90 mmHg or diastolic blood pressure below 55 mmHg (without the use of any antihypertensive treatment), and none of the symptoms described in Group #1.
- •- Group #3: Asymptomatic normal blood pressure individuals
- •Defined as having systolic blood pressure between 110 and 140 mmHg, and diastolic blood pressure between 60 and 85 mmHg (without the use of any antihypertensive treatment), and none of the symptoms described in Group #1.
- •- Group #4: Asymptomatic untreated high blood pressure individuals
- •Defined as having at least one of: systolic blood pressure above 155 mmHg or diastolic blood pressure above 90 mmHg, not using any antihypertensive treatment, and having none of the symptoms described in Group #1.
- •- Group #5: Treated high blood pressure individuals
- •Defined as having systolic blood pressure below 125 mmHg and diastolic blood pressure below 75 mmHg, together with a medical history of hypertension and the use of any antihypertensive medication for at least the past 1 year.
排除标准
- •visual acuity less than 0.8
研究者
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