The Effects of Blood Pressure on Cognitive Function: Examining the Use of Bedside Neuropsychological Testing During Acute Hypertensive Events
概览
- 阶段
- 不适用
- 干预措施
- 未指定
- 疾病 / 适应症
- Hypertension
- 发起方
- Emory University
- 入组人数
- 234
- 试验地点
- 1
- 主要终点
- DETECT neurocognitive outcome scores (Z-scores) in association with blood pressure measures and retinal pathology (isolated retinal hemorrhage, grade III/IV hemorrhagic retinopathy)
- 状态
- 已完成
- 最后更新
- 4年前
概览
简要总结
The purpose of this study is to study the impact of blood pressure on cognitive performance.
详细描述
Four groups will be evaluated for possible impact of blood pressure on cognitive performance and retinal damage.
研究者
Tamara Espinoza, MD
Assistant Professor
Emory University
入排标准
入选标准
- •Patients triaged to the Grady Memorial Hospital Emergency Department or Marcus Trauma Unit
- •Age \>18 and \<65
- •Documented history of hypertension plus one or more of the following:
- •current antihypertensive use with controlled blood pressure
- •elevated Emergency Department systolic blood pressure or diastolic blood pressure
- •Acutely elevated Emergency Department systolic blood pressure or diastolic blood pressure on 2 separate Emergency Department measurements in the absence of a history of hypertension
- •Normal systolic blood pressure or diastolic blood pressure in the absence of hypertension.
排除标准
- •Non-English speaking
- •Pre-visit cognitive impairment
- •Physical or psychological impairments that would prohibit comprehension and completion of DETECT testing
- •Inability to obtain adequate fundoscopic photos
- •Acute intoxication, altered mental status, or head injury within the last 6 months
- •Opiate or benzodiazepine administration by treating providers
- •Clinical condition not allowing testing.
结局指标
主要结局
DETECT neurocognitive outcome scores (Z-scores) in association with blood pressure measures and retinal pathology (isolated retinal hemorrhage, grade III/IV hemorrhagic retinopathy)
时间窗: 12 months
We aim to determine the correlation (if any) between the severity of blood pressure and DETECT neurocognitive outcomes as well as the correlation (if any) between known Hypertensive retinal disease and DETECT neurocognitive outcomes. Appropriate statistical analysis will be performed to compare clinical retinal findings, BP values, and DETECT neurocognitive test outcomes. Subject level data will only be collected on the day of Emergency Department presentation. Subjects will not be followed after their initial enrollment. The study duration is projected for 12 months
次要结局
- Variance of DETECT scores (Z-score) attributed to reading level(One year study periord (12 months))