ACTRN12609000440224撤回3 期
A multi-centre, randomised clinical trial examining the effect of Clopidogrel versus Aspirin in addition to optimal medical therapy for heart failure on subsequent heart failure hospitalisation and mortality in patients with class III-IV congestive heart failure.
适应症
试验速览
- 阶段
- 3 期
- 状态
- 撤回
- 入组人数
- 1,250
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomised controlled trial
- 主要目的
- Treatment
- 盲法
- Open (masking not used)
入排标准
- 年龄范围
- 18 Years 至 o limit（—）
- 性别
- All
入选标准
- •1. Men or women age >18 years
- •2. Symptomatic heart failure
- •3. Serum N-terminal pro-B-type natriuretic peptide (NT-proBNP) of >600pg/mL
- •OR NT-proBNP >400pg/mLa + Heart Failure (HF) hospitalisation within last 12 months
- •4. Treatment with an angiotensin converting enzyme (ACE) inhibitor (unless not tolerated) and ongoing treatment with a diuretic
- •5. Provision of written informed consent
排除标准
- •1. Contraindication to aspirin or clopidogrel
- •2. Indication for chronic anti-coagulation
- •3. Heart failure due to a reversible cause or hypertrophic or infiltrative cardiomyopathy
- •4. Unstable heart failure or treatment regimen
- •5. Life-limiting systemic illness
- •6. Severe chronic obstructive pulmonary disease (COPD) (as evidenced by history of mechanical ventilation, need for home oxygen, or treatment with oral corticosteroids) for more than 3 continuous days within 12 months
- •7. Conditions that might interfere with protocol compliance
研究者
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