NCT00877825已完成2 期
The Influence of Soy Isoflavnoids on the Hypocholesterolemic Effects of Soy
适应症
试验速览
- 阶段
- 2 期
- 状态
- 已完成
研究概览
简要总结
Isoflavonoids, through their estrogen-like activity, are in part responsible for the cholesterol lowering properties of soy foods. If this is found to be so, then it would be advantageous not only to promote soy consumption, but also to identify and use soy cultivars with high isoflavonoid content in production of soy food products. These foods may have a use in the reduction of serum cholesterol and if they effectively increase the phytoestrogen activity of soy, may have a role in the prevention of other hormone dependent diseases (e.g. osteoporosis, certain cancers) in the same way as natural estrogens.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Single
入排标准
- 年龄范围
- 21 Years 至 —(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •men and post-menopausal women
- •LDL-C > 4.1mmol/L at recruitment
- •living within a 40 km radius of St. Michael's Hospital
排除标准
- •lipid lowering medications
- •clinical or biochemical evidence of diabetes, renal or hepatic disease
- •body mass index (BMI) >38 kg/m2
- •antibiotic use within the last three months
- •hormone replacement therapy
- •smoking or significant alcohol use (>1 drink/d)
- •triglyceride level > 4.0mmol/L
研究者
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