Study of Chemotherapy Side Effects in Cancer Patients: Non-invasive Optical Measurements of the Brain
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 主要终点
- Measurement of brain tissues blood flow
研究概览
简要总结
Currently there is no methodology that can assign a risk of development of chemo brain and thus, studies to understand how and why only some patients develop chemo brain along with studies of potential treatments face major hurdles. This study will define hemodynamic/optical parameters in normal individuals and cancer patients undergoing chemotherapy potentially identifying optical parameters that are associated with the development of chemo brain, leading to new insights into the origin of the chemo brain condition, and importantly potentially identifying parameters that may predict who will develop "chemo brain" in order to directing investigations of therapies.
详细描述
The researcher can use Non-invasive optical imaging, diffuse optical spectroscopic imaging, measure various tissues and can determine chemo brain symptoms. Near infrared diffuse optical imaging is a real-time, non-invasive technique that measures hemodynamic variations based on changes in hemoglobin oxygenation. Tissue in general and the cerebral cortex surface in particular, are transparent to near infrared light.
Direct optical measurement of cerebral hemodynamic parameters is superior to systemic approaches that infer brain levels of hemoglobin. Optical imaging in conjunction with physiologic maneuvers measures vascular tone and reactivity and may permit early detection of changes in physiology that precede the onset of chemo brain symptoms. Since chemo brain specifically impacts working memory and executive function the optical imaging can measure the frontal cortical areas behind the forehead.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •have a histologically proven cancer.
- •Planned initiation of chemotherapy
- •age range between 18-70 years
排除标准
- •have NO a histologically proven cancer.
- •NO planned chemotherapy
- •age less than 18 years
结局指标
主要结局
Measurement of brain tissues blood flow
时间窗: 6 months
Diffuse optical spectroscopy and Near infrared spectroscopy are non-invasive methods measure tissue hemodynamics in real time, direct quantitative information and insights treatment-associated toxicity.
次要结局
未报告次要终点
研究者
Beckman Laser Institute and Medical Center
Edward L. Nelson, M.D, Associate Professor of Medicine
University of California, Irvine