Assessment of CT-derived Thoracic Electrical-Impedance-Tomography Finite Element Models
试验速览
- 阶段
- 3 期
- 入组人数
- 160
- 主要终点
- Electrical Impedance Tomography Finite Element Model
研究概览
简要总结
Current EIT analyses are based on the assumption of a circular thorax-shape and do not provide any information on lung borders. The aim is to obtain the body and lung border contours of male subjects by multi-detector computed tomography (MDCT) in defined thresholds of anthropometric data (gender = male; height; weight) for calibration of more realistic EIT reconstruction models.
详细描述
A major drawback of EIT is its relatively poor spatial resolution and its limitation in measuring changes in bioimpedance as compared to a reference state (and not absolute quantities). Therefore, the technique cannot differentiate between extrapulmonary structures (muscles, thorax, heart, large vessels, spine, etc.) and non-aerated lung tissues - which is a major limitation for the clinical use of information derived from EIT-imaging. Moreover, current EIT-reconstruction algorithms are based on the consideration of a complete circular thoracic shape and do not take into account the body contours and lung borders.
The investigators are convinced that EIT-derived dynamic bedside lung imaging can be advanced by morphing computed tomography (CT) scans of the respective thoracic levels with concomitant EIT images - thus enhancing EIT-image information with CT-data. Integrating the anatomy of thoracic shape and lung borders provided by high-spatial resolution multi detector CT-scans (MDCT) with high-temporal resolution EIT has the potential to improve image quality considerably. This data can be used to compute mean EIT-reconstruction models that further offer the possibility to develop novel and clinically meaningful EIT parameters.
Therefore, the investigators hypothesize that by integration of CT-scan information of body and lung contours (and by computing different EIT reconstruction models) the current methodological limitations of EIT technology can be overcome.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •spontaneous breathing male subjects
- •age > 18,
- •clinical indication for thoracic CT scanning,
- •matching of weight and height to the predefined model-thresholds
排除标准
- •pre-existing chronic pulmonary disease
- •skin lesions / wounds in the thoracic plane where the EIT SensorBelt will be attached
- •known allergy against any ingredient of the used ContactAgent
- •abnormalities in thoracic shape as defined by the radiologist in charge (e.g. extreme kyphosis, funnel chest, pigeon breast, multiple rip fractures)
- •pneumothorax
- •pace maker (external and internal)
- •other implanted electrical devices
- •other methods measuring bioimpedance
结局指标
主要结局
Electrical Impedance Tomography Finite Element Model
时间窗: approximately 1 year through study completion
Based on CT-derived thorax, lung and heart contours we propose to calculate human finite element models (FEM) for EIT analysis
次要结局
- weight(at the time-point of inclusion)
- gender(at the time-point of inclusion)
- height(at the time-point of inclusion)
研究者
Ass.-Prof. Dr. Stefan Boehme
MD
Medical University of Vienna