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临床试验/NCT05380570
NCT05380570进行中(未招募)不适用

Health Effects Associated With Occupational Radiation Exposure Among Korean Radiation Workers (Korean Radiation Workers Study)

Korea Institute of Radiological & Medical Sciences1 个研究点 分布在 1 个国家目标入组 196,379 人开始时间: 2021年11月18日最近更新:
适应症
干预措施

试验速览

阶段
不适用
状态
进行中(未招募)
入组人数
196,379
试验地点
1
主要终点
Radiation-induced cancer risk

研究概览

简要总结

Health risks of radiation exposure in the moderate-to-high dose range have been well established. However, the risk remains unclear at low-dose ranges with protracted low-dose rate exposure, which is typical of occupational exposure. The purpose of this study is to construct a cohort of Korean radiation workers and to assess health effects associated with occupational radiation exposure. The study population is expected to be about 190,000 Korean radiation workers who have been registered with the Nuclear Safety and Security Commission since 1984. The national dose registry, the national cancer registry, the national vital statistics registry, and the national health insurance data are collected based on the Nuclear Safety Act. Through the linkage of those collected data, we will evaluate radiation-induced health risks including cancer and non-cancer diseases.

详细描述

The study population of this study is approximately 190000 Korean radiation workers registered with the Nuclear Safety and Security Commission since 1984. Diagnostic medical radiation workers were not included in the study population. The national dose registry, the national cancer registry, the national vital statistics registry, and the national health insurance data for radiation workers are collected retrospectively or prospectively based on the Nuclear Safety Act. Through the linkage of those collected data, we will evaluate radiation-induced health risks including cancer and non-cancer diseases. This data collection will be continued at 5-year intervals to update information on existing study participants and recruit newly hired workers if possible.

Age- and sex-specific standardized incidence and mortality ratios will be calculated for overall comparisons of cancer and non-cancer disease risks with general population. For dose-response assessment, excess relative risk (per Gy) and excess absolute risk (per Gy) will be estimated with adjustments for age and potential confounders, such as lifestyle factors and socioeconomic status.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Prospective

入排标准

年龄范围
16 Years 至 —(Child, Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Korean radiation workers in the national dose registry (except for diagnostic medical radiation workers)

排除标准

  • Unidentified personal identification numbers
  • Foreigner

研究组 & 干预措施

Korean radiation workers

The study population is Korean radiation workers exposed to ionizing radiation in workplaces. Diagnostic medical radiation workers were not included in the study population.

干预措施: Occupational radiation exposure (Radiation)

结局指标

主要结局

Radiation-induced cancer risk

时间窗: year 9

Cancer risk associated with occupational radiation exposure

Radiation-induced cancer risk

时间窗: year 4

Cancer risk associated with occupational radiation exposure

次要结局

  • Radiation-induced non-cancer risk(year 9)
  • Radiation-induced non-cancer risk(year 4)

研究者

申办方类型
Other Gov
责任方
Sponsor

研究点 (1)

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