Daily Light Exposure Patterns and Their Associations With Migraine Outcomes and Sleep Quality
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Change in Monthly Migraine Days
研究概览
简要总结
The purpose of this study is to examine the relationship between daily light exposure patterns, sleep quality, and migraine characteristics in adults with migraine, with and without photophobia, across an 8-week study period.
详细描述
Migraine is a prevalent neurological disorder that significantly reduces quality of life and daily functioning. Photophobia, or heightened sensitivity to light, is one of the most common and distressing symptoms experienced by individuals with migraine and is frequently reported as a trigger or exacerbating factor for migraine attacks. Additionally, sleep disturbances are commonly associated with migraine and may both contribute to and result from migraine episodes. Despite growing evidence linking light exposure, sleep quality, and migraine characteristics, the role of daily light exposure characteristics in triggering migraine attacks remains poorly understood.
Previous research has largely focused on controlled laboratory studies examining the effects of specific light spectra or intensities during migraine attacks. However, little is known about how individuals with migraine experience and interact with light throughout their daily lives, or how these real-world exposure patterns relate to sleep quality and migraine onset, frequency, and severity.
The purpose of this study is to examine the relationship between daily light exposure patterns, sleep quality, and migraine characteristics in adults with migraine, with and without photophobia, across an 8-week study period. The first 4 weeks will serve as a baseline observational period in which participants' daily light exposure behaviors, sleep patterns, and migraine characteristics are monitored. The second four weeks will include the introduction of an interventional lighting condition, optimized for those in migraine based on our previous in-laboratory experiment, on the same outcomes (migraine characteristics and sleep).
Using wearable light exposure sensors, actigraphy devices, and daily self-reported measures, this study aims to capture real-world lighting behaviors and objectively assess sleep quality while evaluating whether the introduction of an optimized lighting condition is associated with changes in migraine symptoms and sleep outcomes.
The specific aims of this study are to:
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Meet the International Classification of Headache Disorders, 3rd edition (2018) criteria for migraine, with or without aura or photosensitivity
- •Report experiencing more than 4 headache days per month and at least three migraine attacks per month
- •No other major health issues based on self-reported data
- •Able to read and communicate in English
- •Work in a private office space for at least six hours per day, four days per week
排除标准
- •Light therapy
- •Use light-altering devices (e.g., blue-blocking contact lenses or glasses)
- •Traveling out of town during the participation
研究组 & 干预措施
Optimized Lighting Intervention
All participants will complete a 4-week baseline observation period followed by a 4-week intervention period. During the baseline period, daily light exposure, sleep, and migraine characteristics will be monitored under natural conditions. During the intervention period, participants will use an optimized workplace lighting condition during working hours while continuing wearable monitoring and daily electronic surveys. Outcomes during the intervention period will be compared to baseline measurements within participants.
干预措施: Ambient Lighting Condition (Other)
结局指标
主要结局
Change in Monthly Migraine Days
时间窗: Baseline (Weeks 1-4) compared to Intervention (Weeks 5-8)
Number of migraine days per 28-day period as recorded in daily electronic headache diaries. A migraine day is defined as a calendar day with a self-reported migraine meeting International Classification of Headache Disorders (ICHD-3) criteria. The primary analysis will compare the 4-week baseline period to the 4-week intervention period within participants.
次要结局
- Change in Migraine Headache Intensity(Baseline (Weeks 1-4) compared to Intervention (Weeks 5-8))
- Change in Migraine-Specific Quality of Life (MSQ v2.1) Score(Baseline (Week 0), Between Baseline and Intervention (end of Week 4), and End of Intervention (Week 8).)
- Change in Objective Sleep Efficiency(Baseline (Weeks 1-4) compared to Intervention (Weeks 5-8))
- Change in Average Daily Ambient Light Intensity(Baseline (Weeks 1-4) compared to Intervention (Weeks 5-8))
- Feasibility of Workplace Lighting Intervention(Intervention Period (Weeks 5-8))
- Change in Objective Nighttime Sleep Duration(Baseline (Weeks 1-4) vs Intervention (Weeks 5-8))
- Change in Average Daily Melanopic Equivalent Daylight Illuminance(Baseline (Weeks 1-4) vs Intervention (Weeks 5-8))
研究者
Nina Sharp
Assistant professor
Arizona State University