Assessment of modulation of activity of Paraoxonase-1 (PON-1) by statins in patients requiring statin therapy. - PSS

Research Society Seth GSMC and KEM Hospital0 个研究点目标入组 140 人开始时间: 待定最近更新: 2021年11月24日

试验速览

暂无简介。

•1. Statin naÃ¯ve patients aged between 18 -75 years of either gender, eligible for statin treatment as per the physicianâ??s diagnosis
•2. Patient willing to give written informed consent

•1. Patients having contraindication to statin like
•a)Chronic renal failure or serum creatinine > 1.7 times the upper limit
•b)Unexplained serum CK > 3 times the upper limit of normal Active hepatitis or cholestasis or ALT > 2 times the upper limit of normal.
•c)Subjects taking one of the following medications and unable to maintain a stable dose at least four weeks prior to the screening visit and for the duration of the study: tamoxifen, raloxifene, estrogen and or progestins, thiazide diuretics, isotretinoin, Ã?-blockers, thyroid hormones, androgens, fiber supplements, protease inhibitors.
•2. Patients requiring any other lipid lowering agent other than statins.
•3. Patients having co-morbidities like any liver disease.
•4. Pregnant and lactating women.
•5. Inability to comply with the treatment and study protocol as per the investigatorâ??s judgment.
•6. History of alcohol and substance abuse in last four weeks.

发起方

Research Society Seth GSMC and KEM Hospital