A Non-Randomized Controlled Cross-Sectional Study to Compare Genetic Variations of IGF-I and IGF-II in Patients With Moderate to Severe Dementia and Younger Family Members, in Relation to Age-Matched Unaffected Controls
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Genetic polymorphisms of insulin-like growth factors
研究概览
简要总结
The purpose of this study is to determine if insulin-like growth factors (IGF) play a role in the development of dementia, specifically Alzheimer's disease (AD). The study will compare results from genetic testing between patients with AD and two other groups: younger biological family members of the AD patients and individuals without AD matched by age to the AD patients.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 50 Years 至 81 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Men and women between the ages of 50 and 81 years old who have a diagnosis of dementia
- •Men and women who are at least 18 years old and are biologically related to the study subject with dementia
- •Control subjects must not have a diagnosis of dementia and must be matched in age to the study subjects with dementia
排除标准
- •Biological family members of the dementia patient who are either younger than 17 years of age or older than the patient with dementia
- •Biological family members with a diagnosis of dementia
- •Age-matched control subjects with a diagnosis of dementia
结局指标
主要结局
Genetic polymorphisms of insulin-like growth factors
时间窗: Single clinic visit (day 1)
This study consists of a single clinic visit. After subject has completed the informed consent process and meets eligibility criteria, a blood sample and a saliva sample will be collected. Genetic results from this one-time specimen collection will be evaluated and compared with results from participants in the other two study groups. Outcomes will be measured comparatively.
次要结局
- Genetic testing of Apolipoprotein (APO) E4(Single clinic visit (day 1))