Effect of Ventilation Mode on Lung Deposition of a Radiolabeled Aerosol During Mechanical Ventilation: Barometric Versus Volumetric
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 19
- 试验地点
- 1
- 主要终点
- Pulmonary deposition
研究概览
简要总结
Controlling the respiratory pattern of mechanically ventilated patients in volume control mode is recommended during nebulization. No studies looked into conditions of nebulization during assisted mechanical ventilation to define the optimal nebulization technique and its effect on pulmonary deposition.
The aim of this study is to analyse the effect of ventilation mode (barometric versus volumetric) on deposition by planar scintigraphy during mechanical ventilation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Invasive mechanical ventilation
- •Healthy lungs
排除标准
- •Change of ventilation mode during nebulization
研究组 & 干预措施
Nebulization during volume assist control mode
Patients ventilated in volume assist control mode during nebulization
干预措施: Gamma scintigraphy (Other)
Nebulization during volume assist control mode
Patients ventilated in volume assist control mode during nebulization
干预措施: Preoperative spirometry (Other)
Nebulization during pressure support ventilation
Patients ventilated in pressure support mode during nebulization
干预措施: technetium-99m - Diethylenetriaminepentaacetic acid (Drug)
Nebulization during pressure support ventilation
Patients ventilated in pressure support mode during nebulization
干预措施: Vibrating-mesh nebulizer (Device)
Nebulization during pressure support ventilation
Patients ventilated in pressure support mode during nebulization
干预措施: Gamma scintigraphy (Other)
Nebulization during pressure support ventilation
Patients ventilated in pressure support mode during nebulization
干预措施: Preoperative spirometry (Other)
Nebulization during volume assist control mode
Patients ventilated in volume assist control mode during nebulization
干预措施: technetium-99m - Diethylenetriaminepentaacetic acid (Drug)
Nebulization during volume assist control mode
Patients ventilated in volume assist control mode during nebulization
干预措施: Vibrating-mesh nebulizer (Device)
结局指标
主要结局
Pulmonary deposition
时间窗: Immediately after nebulization by imaging assessment, an expected average of 30 minutes
次要结局
- Penetration index(Immediately after nebulization by imaging assessment, an expected average of 30 minutes)
- Lung function(Preoperative assessment, the day before inclusion)
- Mechanical ventilation settings(During nebulisation time, an expected average of 15 minutes)