Improving Critical Power and Muscle Function in Older Adults With Heat Therapy
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 148
- 试验地点
- 2
- 主要终点
- Muscle Critical Power
研究概览
简要总结
Exercise tolerance decreases with age and a sedentary lifestyle. Muscle critical power (CP), is a sensitive measure of exercise tolerance that is more even more relevant to and predictive of endurance performance than VO2max.
While recent evidence indicates that CP and muscle function decrease with aging, the cause of this decrease in CP and the best way to mitigate the decrease in CP are unknown.
This study will:
- Measure knee extensor CP in young and old individuals and determine the extent to which changes in muscle oxygen delivery (e.g. resistance artery function, maximum exercise blood flow), muscle mass and composition (e.g. whole-muscle size, muscle fiber cross-sectional area) and mitochondrial oxygen consumption (e.g. maximal coupled respiration of permeabilized fibers biopsied from the knee extensors) contribute to the decrease in CP with age.
- Examine the effectiveness of two different therapies (1. High Intensity Interval Training, HIIT and 2. Muscle Heat Therapy) at improving muscle function and critical power in young and older adults.
- Examine the impact of muscle disuse (2 weeks of leg immobilization), a potential contributor to the decrease in muscle function with aging, on muscle function and critical power and determine if heat therapy is an effective means of minimizing the impact of disuse on muscle function and critical power.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Participant)
盲法说明
Subjects assigned to the heat therapy and the sham heat therapy will not know if they are truly receiving the heat therapy or not. The muscle heater (shortwave diathermy) will be placed on the muscle during each visit, but, unbeknownst to the heat and sham group, will not be turned on for the sham group.
入排标准
- 年龄范围
- 18 Years 至 95 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •18-95 years of age
- •Currently no cardiovascular or metabolic disease (e.g. heart failure, diabetes)
- •ability to perform knee extension exercise
排除标准
- •Current cardiovascular or metabolic disease (e.g. heart failure, diabetes)
- •participating in exercise training within the last 6 months
- •inability to perform knee extension exercise
结局指标
主要结局
Muscle Critical Power
时间窗: 3-8 weeks
Muscle exercise tolerance, quantified as critical power, will be assessed before and after each intervention. The main outcome will be the change in critical power, expressed in Watts, elicited by each intervention. Specifically, participants will perform 3-5 different power outputs of single leg knee extension exercise as long as they can. Subsequently, the line of best fit between the total work performed and duration of each power output trial will be used to quantify critical power, expressed in Watts.
次要结局
- Muscle Fiber Size(3-8 weeks)
- Muscle Mitochondrial Function(3-8 weeks)
- Resistance Artery Function(3-8 weeks)
- Maximum Exercise Blood Flow(3-8 weeks)
- Vastus Lateralis Cross-Sectional Area(3-8 weeks)
研究者
Jayson Gifford
Assistant Professor
Brigham Young University