Resistance Exercise Training at Different Intensities in Healthy and Frail Older People: A Feasibility Study
试验速览
- 阶段
- 不适用
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Number of training sessions attended
研究概览
简要总结
After the age of 40-45 years muscle mass and function progressively decline, reducing older peoples' abilities to perform tasks of daily living and also increase the risk of falls. It is known that, across the life course, resistance exercise can be of benefit in increasing muscle mass and function, yet how hard the exercise should be performed has received little attention. Current recommendations are for older people to perform exercise at 70% of the maximum they can lift, quite a high intensity that often puts older people off participating. Recent evidence in younger people has suggested that such intensities are not required.
The investigators aim to determine the feasibility of a study to investigate recruitment and adherence of older people to a study of exercise training at different intensities.
详细描述
The cohort will comprise two sets of participants: frail older adults and non-frail older adults.
Each participant will receive 8 weeks of twice weekly supervised resistance training. Both the frail and non-frail participants will be randomised into either receiving high load resistance training or low load resistance training. High load resistance training will be delivered at 70% of the participants maximal capacity and low load resistance training will be delivered at 30% of maximal capacity. All resistance training will focus on the lower limb and regardless of intensity each exercise will be done to failure (unable to complete another full repetition).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 65 Years 至 —（Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Non-frail - Over 65 years of age Frail - Over 65 years of age, Three or more of the following criteria: >10lbs of weight loss unintentionally in previous year; grip strength in lowest 20% (by sex and BMI); self-reported exhaustion; walking time for 15 feet in slowest 20% (by sex and height); physical activity in the lowest 20%.
排除标准
- •Non-frail - Current participation in an exercise programme. Clinical team do not think resistance exercise would be safe or unable to consent. Any other reason that precludes participation in exercise, decision made by research team in consultation with a consultant in Geriatric Medicine where required.
- •Frail - Current participation in an exercise programme. Clinical team do not think resistance exercise would be safe or unable to consent. Any other reason that precludes participation in exercise, decision made by research team in consultation with a consultant in Geriatric Medicine where required.
研究组 & 干预措施
High load non-frail
Non-frail participants who will receive resistance training at 70% of their maximal strength
干预措施: resistance training (Other)
low load non-frail
Non-frail participants who will receive resistance training at 30% of their maximal strength
干预措施: resistance training (Other)
high load frail
Frail participants who will receive resistance training at 70% of their maximal strength
干预措施: resistance training (Other)
low load frail
Frail participants who will receive resistance training at 30% of their maximal strength
干预措施: resistance training (Other)
结局指标
主要结局
Number of training sessions attended
时间窗: 8 weeks
Expressed as a percentage of number of sessions attended
Compliance with protocol
时间窗: 8 weeks
Expressed as a percentage of number of sessions where training protocol was adhered to
Number of treatment-related adverse events as assessed by CTCAE v4.0
时间窗: 8 weeks
Number of adverse events that could be attributed to the intervention
Acceptability of intervention (qualitative)
时间窗: 8 weeks
focus groups with semi-structured discussion plans will investigate the acceptability of the intervention
次要结局
- Muscle strength(8 weeks)
- Muscle power(8 weeks)
- Muscle thickness(8 weeks)
- Frailty(8 weeks)
- Quality of life(8 weeks)
- Functional abilities(8 weeks)
- motion analysis(8 weeks)
- Activities of daily living(8 weeks)
研究者
Dr Evan Campbell
Research Associate
University of Glasgow