Evaluation of the Effects of a Combined Resistance and High-intensity Interval Exercise Training Program, Along With Nutritional Supplementation, on Strength and Physical Function in Older Men
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Aging
- Sponsor
- McMaster University
- Enrollment
- 50
- Locations
- 1
- Primary Endpoint
- Muscle mass
- Status
- Completed
- Last Updated
- 7 years ago
Overview
Brief Summary
As we age we tend to lose muscle mass and strength. These losses contribute to the increased incidence of falls and fractures, metabolic diseases such as type 2 diabetes, loss of independence and reduced quality of life in the elderly. As the number of seniors increases worldwide, it is becoming more and more important to develop strategies to counteract this loss of muscle mass and strength, and promote healthy aging. Fortunately, relatively simple lifestyle modifications are the most potent defense strategies. Exercises such as weight lifting and high-intensity interval exercise (HIIT), which consists of short, repeated bouts of vigorous aerobic exercise interspersed with period of rest, are the most effective in promoting gains in muscle mass and strength. Additionally, components of foods like whey (a protein found in milk), creatine (found in meat), calcium and vitamin D have been shown to independently increase strength. In this study, we are looking to determine how much we can increase muscle strength in older men who are put on an 12 week exercise training program that combines weight lifting and HIIT, and who consume a daily supplement that contains whey protein, creatine, calcium and vitamin D.
Detailed Description
Please see other documentation.
Investigators
Stuart Phillips
Principal Investigator
McMaster University
Eligibility Criteria
Inclusion Criteria
- •Sedentary (no participation in a structured exercise training program in past 6 months)
- •BMI between 18.5-30.0 kg/m2
- •Weight stable for past 6 months
- •Normal resting blood pressure, or stage I hypertension
Exclusion Criteria
- •Use of simvastatin or atorvastatin
- •Use of non-steroidal anti-inflammatory drugs
- •Injuries that prevent safe-participation in an exercise training program
- •Prescription blood thinners
- •Diabetes or other metabolic disorders
- •Cardiac or gastro-intestinal problems
- •Infectious disease or cancer
Outcomes
Primary Outcomes
Muscle mass
Time Frame: 12 weeks
DXA, ultrasound
Secondary Outcomes
- Muscle protein synthesis(12 weeks)
- Satellite cell number, density, type I/type II fibre specific satellite cells and myonuclear domain(12 weeks)
- Glycemic control(12 weeks)
- Cognitive function(12 weeks)