Evaluation of the Effects of a Combined Resistance and High-intensity Interval Exercise Training Program, Along With Nutritional Supplementation, on Strength and Physical Function in Older Men
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 50
- 试验地点
- 2
- 主要终点
- Muscle mass
研究概览
简要总结
As we age we tend to lose muscle mass and strength. These losses contribute to the increased incidence of falls and fractures, metabolic diseases such as type 2 diabetes, loss of independence and reduced quality of life in the elderly. As the number of seniors increases worldwide, it is becoming more and more important to develop strategies to counteract this loss of muscle mass and strength, and promote healthy aging. Fortunately, relatively simple lifestyle modifications are the most potent defense strategies. Exercises such as weight lifting and high-intensity interval exercise (HIIT), which consists of short, repeated bouts of vigorous aerobic exercise interspersed with period of rest, are the most effective in promoting gains in muscle mass and strength. Additionally, components of foods like whey (a protein found in milk), creatine (found in meat), calcium and vitamin D have been shown to independently increase strength. In this study, we are looking to determine how much we can increase muscle strength in older men who are put on an 12 week exercise training program that combines weight lifting and HIIT, and who consume a daily supplement that contains whey protein, creatine, calcium and vitamin D.
详细描述
Please see other documentation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 60 Years 至 —(Adult, Older Adult)
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Sedentary (no participation in a structured exercise training program in past 6 months)
- •BMI between 18.5-30.0 kg/m2
- •Weight stable for past 6 months
- •Normal resting blood pressure, or stage I hypertension
排除标准
- •Use of simvastatin or atorvastatin
- •Use of non-steroidal anti-inflammatory drugs
- •Injuries that prevent safe-participation in an exercise training program
- •Prescription blood thinners
- •Diabetes or other metabolic disorders
- •Cardiac or gastro-intestinal problems
- •Infectious disease or cancer
研究组 & 干预措施
Supplement
Each day, participants in this group will receive a supplement that provides a total of protein, creatine monohydrate, calcium, vitamin D and carbohydrate. This supplement will be provided to participants in beverage format, twice daily.
干预措施: Supplement (Dietary Supplement)
Placebo
The placebo will provide participants with maltodextrin (carbohydrate) and sucrose.
干预措施: Supplement (Dietary Supplement)
结局指标
主要结局
Muscle mass
时间窗: 12 weeks
DXA, ultrasound
次要结局
- Muscle protein synthesis(12 weeks)
- Satellite cell number, density, type I/type II fibre specific satellite cells and myonuclear domain(12 weeks)
- Glycemic control(12 weeks)
- Cognitive function(12 weeks)
研究者
Stuart Phillips
Principal Investigator
McMaster University
