Comparison of the Benefits of Prolonged Resistance-type Exercise Training in the Older Population Aged 65-75 y Versus 85 y and Over
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Universidad de La Frontera
- Enrollment
- 31
- Locations
- 1
- Primary Endpoint
- Change in skeletal muscle mass (measured via Computed tomography (CT) scan) after prolonged resistance-type exercise training
Study Overview
Brief Summary
Background: Aging is associated with muscle mass and strength loss and "oldest" old people (≥85 y) are at a far greater risk of developing sarcopenia. Training increases muscle mass and strength in a variety of populations, yet the efficacy has not been clearly defined for individuals in the fourth age (≥80 y).
Hypothesis: The following hypotheses will be investigated:
- Twelve weeks of progressive resistance-type exercise training increases muscle mass and strength in young old (65-75 y) and oldest old (85 y and over) subjects.
- The training-induced increase in muscle mass and strength is relatively greater in young old subjects when compared to oldest old subjects.
Goals: The primary aim of this study is to compare the effect of resistance-type exercise training on skeletal muscle mass (i.e. quadriceps cross-sectional area and whole body lean mass) in young old and oldest old subjects.
Specific goals
- Determine whether resistance-type exercise training can increase muscle mass and muscle strength in young old and oldest old subjects.
- Determine whether resistance-type exercise training can improve physical performance in young old and oldest old subjects.
- Identify whether inflammatory markers (i.e., TNFα, IL-4, IL-6, IL-10, IL-13) are up- or down-regulated in young old and oldest old subjects before and after resistance-type exercise training.
Methodology:
Study design Sixty older females and males (young old group: n=30, 65-75 y; oldest old group: n=30, 85 y and over) will be included in this prospective clinical trial. All volunteers will be subjected to 12 weeks of whole-body resistance-type exercise training (3x/wk). Before, and after 6 and 12 weeks of training, a computed tomography (CT) scan of the upper leg will be performed to assess quadriceps cross sectional area. On those days, fasting blood samples will be obtained and whole-body dual energy x-ray absorptiometry (DEXA) scan will also be performed. Maximal strength will be determined by 1-repetition maximum (1RM) and physical functioning by the short physical performance battery (SPPB) at the same time points.
Detailed Description
Background: Aging is associated with muscle mass and strength loss and "oldest" old people (≥85 y) are at a far greater risk of developing sarcopenia. Training increases muscle mass and strength in a variety of populations, yet the efficacy has not been clearly defined for individuals in the fourth age (≥80 y). A better understanding of the skeletal muscle adaptive response to resistance-type exercise training with advanced age will provide a strong basis to develop and implement care programs within our rapidly aging population, in which the "oldest" old represent the fastest growing group.
Hypothesis: The following hypotheses will be investigated:
- Twelve weeks of progressive resistance-type exercise training increases muscle mass and strength in young old (65-75 y) and oldest old (85 y and over) subjects.
- The training-induced increase in muscle mass and strength is relatively greater in young old subjects when compared to oldest old subjects.
Goals: The primary aim of this study is to compare the effect of resistance-type exercise training on skeletal muscle mass (i.e. quadriceps cross-sectional area and whole body lean mass) in young old and oldest old subjects.
Specific goals
Study Design
- Study Type
- Interventional
- Allocation
- Non Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Treatment
- Masking
- Single (Outcomes Assessor)
Eligibility Criteria
- Ages
- 65 Years to — (Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Aged from 65-75 and 85 and more years.
- •18.5 < BMI < 30 kg/m
- •Older people that are still "community-dwelling", i.e., not living in a nursing-home or elderly-home.
Exclusion Criteria
- •Performing regular resistance training (2 or more times per week, carrying out progressive training) in the previous 6 months.
- •Cardiovascular diseases that are contradictory for physical activity (not included controlled Hypertension).
- •All co-morbidities interacting with mobility and muscle metabolism of the body and that do not allow to (safely) perform the resistance-type exercise program (e.g. debilitating arthritis, spasticity/rigidity, all neurological disorders and paralysis).
Outcomes
Primary Outcomes
Change in skeletal muscle mass (measured via Computed tomography (CT) scan) after prolonged resistance-type exercise training
Time Frame: Before, and after 6 and 12 weeks of training
Cross-sectional area of the quadriceps and L3 region via single-slice CT scan
Secondary Outcomes
- Change in lean tissue (measured via Dual Energy X-ray Absorptiometry (DEXA) scan) after prolonged resistance-type exercise training(Before, and after 6 and 12 weeks of training)
- Change in Inflammatory markers via ELISA after prolonged resistance-type exercise training(Before, and after 6 and 12 weeks of training,)
- Change in hand grip strength (measured via JAMAR handheld dynamometer) after prolonged resistance-type exercise training(Before, and after 6 and 12 weeks of training)
- Change in physical performance (measured via Short physical performance battery (SPPB)) after prolonged resistance-type exercise training(Before, and after 6 and 12 weeks of training)
- Change in arms and legs strength (measured via 1-Repetition Maximum (1RM) testing) after prolonged resistance-type exercise training(Before, and after 6 and 12 weeks of training)
Investigators
Gabriel Nasri Marzuca-Nassr
Professor
Universidad de La Frontera