Role of Anesthesia / Surgery on Cognitive Function in Child
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 发起方
- 试验地点
- 1
- 主要终点
- Global cognitive abilities
研究概览
简要总结
The role of surgical stress and anesthesia is unknown in the early childhood. In vitro and animal studies showed a risk for treatment with anesthesia in the developmental brain. Furthermore, stress is also an important risk factor for cognitive impairment. Therefore, the investigators want to investigate in a clinical prospective cohort study the role anesthesia and surgery on different cognitive parameters and self-controling mechanisms in children under 3 years.
详细描述
In order to investigate the role of anesthesia and / or surgery on cognitive abilities the investigators want to perform a prospective cohort study in children under 3 years. Three groups should be compared: i) control without anesthesia / surgery, ii) children with only anesthesia, and iii) children with both surgery and anesthesia. All children will be investigate before and after intervention. Different behavioral scales will be used for detailed cognitive abilities and self-regulatory skills.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 9 Months 至 3 Years（Child）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age 9 month to 3 years with or without anesthesia / surgery
排除标准
- •Psychiatrical, neurological, oncological diseases
结局指标
主要结局
Global cognitive abilities
时间窗: 4-6 weeks
Early Childhood Behavior Questionnaire (ECBQ) questionnaire
次要结局
- surgery-associated data(1 day)
研究者
Konstanze Plaschke
Prof.
Heidelberg University