Efficacy of Pericapsular Nerve Group Block After Total Hip Arthroplasty Surgery
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 60
- 试验地点
- 2
- 主要终点
- Total morphine consumption
研究概览
简要总结
Controlling pain after hip replacement surgery improves comfort and partient satisfaction. Pain after hip replacement has traditionally been managed using systemic pain medications including acetaminophen and non-steroidal anti-inflammatory drugs. A recent Cochrane review demonstrated that compared to systemic analgesia alone, peripheral nerve blocks reduce postoperative pain with moderate-quality evidence. Pericapsular Nerve Group block is a new technique allowing local anesthetic diffusion to femoral, obturator and accessory obturator nerves and providing a good analgesic effect for hip fracture surgery. Investigators hypothesized that the PENG block could be an interesting alternative to systemic analgesiscs for pain control after total hip replacement.
详细描述
The aim of the study was to evaluate the efficacy of the PENG block for intra and postoperative pain control in total hip arthroplasty.
it was a monocentric, randomized, controlled and double blind study. Patients scheduled for primary THA with lateral approach under general anesthesia.
Premedication with IV midazolam 1 to 2 mg on arrival to operating theatre. general anesthesia was conducted using fentanyl, propofol and cisatracurium for induction and isoflurane for maintanance patients were randomized using a random table in two groups:
- PENG Block group (PG) who received 2 mg.kg-1Ropivacaine in 40 ml of saline.
- Placebo group (SG) who received 40 ml of saline.
Postoperative analgesia started before extubation of the patient, with:
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •primary THA with lateral approach under general anesthesia.
排除标准
- •Hip fracture,
- •allergy to local anesthetics,
- •peripheral neuropathy,
- •creatinin clearance inferior to 30ml/min,
- •weight inferior to 50 Kg or superior to 100 Kg,
- •neurological disorder affecting the lower extremity, significant psychiatric conditions,
- •patients receiving corticosteroid therapy,
- •chronic consumption of opioids (>2 months).
结局指标
主要结局
Total morphine consumption
时间窗: day one
morphine consumption on mg
次要结局
- Pain score after extubation(up to 30 minutes)
- postoperative pain score(day one)
- intraoperative opioid consumption(Day 0)
- Pain score during seating position(day one)
研究者
Olfa kaabachi, MD
Professor
University Tunis El Manar