临床试验/NCT01367691

NCT01367691终止不适用

Cardiac MR (CMR) in Cardiac Resynchronization Therapy (CRT) Non-responders: Therapy Optimization by Means of Tissue Characterization, Hemodynamic Analysis and Analysis of Myocardial Activation

University Hospital, Bonn2 个研究点分布在 1 个国家目标入组 1 人开始时间: 2011年6月1日最近更新: 2014年2月3日

适应症

试验速览

阶段: 不适用
状态: 终止
发起方
入组人数: 1
试验地点: 2
主要终点: improvement in NYHA-class

研究概览研究设计入排标准结局指标研究者研究点记录与标识符相似试验

研究概览

简要总结

Cardiac MR (CMR) will be used to assess myocardial activation and hemodynamics in patients with CRT.

Goals are to demonstrate that

differences in Left ventricle (LV)- right ventricle (RV) pacing delays cause differences in myocardial activation
differences in LV-RV pacing delays cause differences in LV/RV hemodynamics

and to use these data to optimize CRT.

详细描述

CMR will be performed in patients under CRT who are currently not responding to CRT. Different LV-RV delays will be programmed during CMR and LV function and different dyssynchrony parameters will be assessed. Results will be used to determine the optimal LV-RV delay, and CRT-devices will be reprogrammed accordingly. Improvement in NYHA-class/conversion to therapy responder will be determined clinically after 3 months.

研究设计

研究类型: Interventional
分配方式: Na
干预模型: Single Group
主要目的: Treatment
盲法: None

入排标准

年龄范围: 18 Years 至 —（Adult, Older Adult）
性别: All
接受健康志愿者: 否

入选标准

•presence of CRT device
•CRT non responder

排除标准

•pregnancy
•end-stage renal failure

结局指标

主要结局

improvement in NYHA-class

时间窗: 6 months

次要结局

safety of CMR in CRT-patients(6 months)

研究者

发起方

University Hospital, Bonn

申办方类型

Other

责任方

Principal Investigator

主要研究者

Claas P. Naehle

Assistant Professor of Radiology

University Hospital, Bonn

研究点 (2)

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