Multimodal Evaluation of Cartilage Lesions of Patellofemoral Joint
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 10
- 试验地点
- 1
- 主要终点
- Evaluation and comparison of histologic analysis, 9,4 Tesla MRI, FFOCT and ultrasound-based navigation system for cartilage lesions analysis of patellofemoral joint.
研究概览
简要总结
Evaluation and comparison of histological analysis, 9,4 tesla MRI, Full-Field Optical Coherence Tomography (FFOCT) and ultrasound-based navigation system for cartilage degeneration analysis of patellofemoral joint.
详细描述
Knee osteoarthritis (OA) is a common and debilitating chronic degenerative disease of the articular cartilage. Despite recent progress in the field of cartilage imaging, no routinely used clinical imaging modality has the ability to evaluate and monitor changes in cartilage degeneration. This observationnal, pilot, prospective, non randomized, uncontrolled, monocentric study aim to compare three of the most innovative imaging systems, namely the 9,4 Tesla MRI, the FFOCT (Full-Field Optical Coherence Tomography) and the ultrasound-based navigation system in order to image healthly to severely degraded human cartilage samples. All methods will be cross-correlated and compared with histological data considered as the gold standard.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Over 18 years of age
- •Knee prosthetic surgery indication with cartilage excision.
排除标准
- •Subjects who refuse to sign a non-objection form
结局指标
主要结局
Evaluation and comparison of histologic analysis, 9,4 Tesla MRI, FFOCT and ultrasound-based navigation system for cartilage lesions analysis of patellofemoral joint.
时间窗: 6 months
Correlation between Osteoarthritis Research Society International (OARSI) grades performed for different modalities
次要结局
- Evaluation of FFOCT reconstructions in early osteoarthritis evaluation using visual qualitative information parameter.(6 months)
- Evaluation of navigation ultrasound in early osteoarthritis evaluation using visual qualitative information parameter.(6 months)
- Inter-observer robustness analysis of the OARSI classification(6 months)
- Evaluation of 9,4 Tesla MRI reconstructions in early osteoarthritis evaluation using visual qualitative information parameter obtained from the Average Pathlength Maps (APM).(6 months)
- Evaluation of FFOCT reconstructions in early osteoarthritis evaluation using visual quantitative information parameter.(6 months)
- Evaluation of of 9,4 Tesla MRI reconstruction in early osteoarthritis evaluation using visual quantitative information parameter obtained for the Average Pathlength Maps.(6 months)
- Evaluation of navigation ultrasound in early osteoarthritis evaluation using visual quantitative information parameter.(6 months)
- Intra-observer robustness analysis of the OARSI classification(6 months)