The 90% Effective Flow of High Flow Nasal Oxygenation During Deeply Sedated Bronchoscopy
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 240
- 试验地点
- 1
- 主要终点
- the incidence of hypoxemia
研究概览
简要总结
Patients undergoing sedated bronchoscopy were randomized into six groups (10 Liters/minute [L/min], 20 L/min, 30 L/min, 40 L/min, 50 L/min, 60 L/min). The primary outcome was the incidence of hypoxemia.
详细描述
It's a double-blind, randomized trial. The patients'demographic information, such as sex, weight, height, smoking status, present illness and history of past illness, were collected. After successful peripheral intravenous access, all patients, before sedation, received 20 min nebulization with lidocaine via a nebuliser facemask. The basic oxygen saturation, heart rate, and blood pressure of the patients were recorded by the investigators.Patients in the HFNO group received humidified oxygen at different rates via a high-flow nasal cannula (AIRVO2, New Zealand). After sedation with propofol and sufentanil, continuous electrocardiography and pulse oximetry were recorded, and the blood pressure of the patients was monitored throughout the procedure. . After bronchoscopy, patients were transferred to the post anesthesia care unit (PACU) if their vital signs were stable.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •(1) undergoing sedated bronchoscopy
- •(2) 18 to 70 years of age;
- •(3) American Society of Anaesthesiologists (ASA) class: I-III
排除标准
- •(1) severe cardiac disease, including aortic stenosis, mitral stenosis, hemodynamic instability caused by severe arrhythmia, and acute myocardial infarction or cardiac surgery within the last 6 months;
- •(2) severe hypoxemia (SpO2 < 90% without oxygen supply on admission), caused by interstitial lung disease, end-stage chronic obstructive pulmonary disease (COPD) or other diseases;
- •(3) upper respiratory tract infection or lung infection;
- •(4) refusal to participate in this study.
结局指标
主要结局
the incidence of hypoxemia
时间窗: during bronchoscopy
hypoxemia was defined as SpO2 \< 90%
次要结局
- jaw thrust maneuver(during bronchoscopy)
- increase of flow rate(during bronchoscopy)
- bag-mask ventilation(during bronchoscopy)
研究者
Wen Zhang
attending, principle investigator, department of anesthesiology
Zhejiang Cancer Hospital