Evaluation of Efficacy of Squill Oxymel in Treatment of Knee Osteoarthritis Compared with placebo.

Traditional Medicine College of Shahid Beheshti University of Medical Sciences0 个研究点目标入组 90 人开始时间: 待定最近更新: 2018年2月22日

适应症

试验速览

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•Inclusion Criteria:
•Age 40 to 80 years old that fill clinical and radiological criteria of ACR. after drug wash out,with VAS>40mm.
•clinical and radiological criteria of ACR: knee pain + osteophite in radiography + at least 1 of 3 below criteria: age up 50 years old; morning stiffness less than 30 minutes; crepitation of knee.

•history of rheumatoid arthritis and gout;
•history of knee surgery;
•patients with severe cardiovascular disease, including heart failure, advanced Class 3 and 4, sick sinus syndrome (SSS), 3rd degree atrioventricular block, Wolff Parkinson's White syndrome (WPW), ventricular tachycardia (VT), hypertrophic cardiomyopathy, aortic thoracic aneurysm;
•proven malignancies;
•GI bleeding(stomach bleeding);
•severe liver disease(esophageal varices and bleeding, encephalopathy, ascites);
•patients with Symptomatic gallstone(in history);
•severe renal disease(creatinine greater than 3mg / dl);
•joint injection of corticosteroids in the past three months;
•received oral corticosteroids in the past 4 weeks;
•oral or injectable NSAID in last seven days;
•received chondrotin sulfate or glucosamine, warfarin, clopidogrel, digitalis, capsaicin, quinidine, laxatives or any other drugs, according to pharmacologists opinion;
•pregnancy and Breast-feeding.
•Exit criteria during study:
•Not wanting to continue taking the drug by the patient for any reason;
•Allergy symptoms or complications to acetaminophen or squill oxymel;
•Any clinical condition that need to change a patient's treatment regimen.

发起方

Traditional Medicine College of Shahid Beheshti University of Medical Sciences