The Clinical Profile of UK Asthma Patients With Raised Blood Eosinophils
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 130,248
- 试验地点
- 1
- 主要终点
- Exacerbations
研究概览
简要总结
To explore the relationship between blood eosinophil counts, asthma exacerbations and patient asthma control using a large primary care based research database
详细描述
Sputum eosinophil levels have been shown to predict asthma exacerbation and inhaled corticosteroid (ICS) responsivenesss. Managing asthma based on sputum eosinophils leads to fewer exacerbations than management adhering to Global Initiative for Asthma (GINA) guidelines. However the use of sputum to measure eosinophil levels is expensive and impractical within a clinical setting. This study explores the use of blood-eosinophil levels as a clinical predictor for exacerbations and asthma control within a UK primary care dataset.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 12 Years 至 80 Years（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patient aged 12-80 at date of last eosinophil count
- •Asthma diagnosis at any time
- •Blood Eosinophil reading in patient record (numeric count expressed in µl) at least one year prior to last data extraction
- •Two years of continuous data
排除标准
- •Any other chronic respiratory diseases
- •Eosinophil counts >5000/µl (outliers)
结局指标
主要结局
Exacerbations
时间窗: 1 year
Defined as: * American Thoracic Society / European Respiratory Society (ATS/ERS) task force definition: Asthma related hospital admissions OR accident and emergency (A\&E) room attendance OR Use of acute oral steroids * Clinical definition: ATS/ERS definition including any GP consultations for lower respiratory related tract infections (LRTIs) treated with antibiotics
Asthma control
时间窗: 1 year
Defined as: * Risk domain asthma control: No Asthma-related hospital attendance, A\&E attendance, out-patient department attendance, no prescriptions for acute oral steroids and no GP consultations for LRTIs treated with antibiotics * Overall asthma control: Risk domain asthma control definition, including average daily dose of ≤200mcg salbutamol
次要结局
未报告次要终点