Department of Anesthesiology in Shenzhen People's Hospital
试验速览
- 阶段
- 早期 1 期
- 发起方
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- the volume of anesthetic drugs
研究概览
简要总结
Putting 80 patients divided into group S（non-intubated general anesthesia combine with Paravertebral blocks、surface spray anesthesia and Vagus block） and group D（non-intubated general anesthesia combine with Paravertebral blocks、surface spray anesthesia、Vagus block and Phrenic block）randomly,compare the volume of anesthetic and the number of increasing anesthetic during operation were compared between the two groups.If the date of group S greater than group D，it shows that the effect of anesthetic effect of group D is better than group S.
详细描述
- Put 80 patients divided into group S（non-intubated general anesthesia combine with Paravertebral blocks、surface spray anesthesia and Vagus block） and group D（non-intubated general anesthesia combine with Paravertebral blocks、surface spray anesthesia、Vagus block and Phrenic block）randomly.
- Compare the volume of anesthetic drugs between the two groups.
- If the date of group S greater than group D，it shows that the effect of anesthetic effect of group D is better than group S.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
盲法说明
Volunteers and data collectors was masked
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •The patient agreed to perform non-intubated video-assisted thoracoscopic surgery, and informed the possibility of intraoperative tracheal intubation or thoracotomy.
- •No conventional anesthesia contraindication, no history of thoracic surgery, good cardiopulmonary function.
- •There is no severe adhesion and calcification in the thoracic cavity, and no artificial pneumothorax is affected.
- •the patient has no serious anxiety or depression.
- •Small surgical trauma, simple steps, short time.
排除标准
- •Mallampati≥
- •BMI≥26 kg/m
- •Hemodynamic instability.
- •Respiratory infection, persistent cough or airway mucus hypersecretion, high risk of reflux.
- •nervous system disease,such as seizure or brain edema.
- •Extensive pleural adhesions or once chest surgery.
- •PaO2<60mmHg or PaCO2>50 mmHg.
- •Central hypopnea syndrome.
- •Lung isolation should be used to protect the healthy side of the lung.
- •Complicated operation, large trauma, long time, lack of experience or poor cooperation in the surgical team.
- •Contraindications to local anesthetic.
研究组 & 干预措施
phrenic block group
non-intubated general anesthesia combine with Paravertebral blocks、surface spray anesthesia、Vagus block and Phrenic block
干预措施: phrenic block (Procedure)
Control group
non-intubated general anesthesia combine with Paravertebral blocks、surface spray anesthesia and Vagus block
干预措施: no phrenic block (Procedure)
结局指标
主要结局
the volume of anesthetic drugs
时间窗: the time of operation， an average of 4 hours
the volume of anesthetic drugs including sevoflurane,propofol and opioids during the operation
次要结局
- the time to get out of bed after surgery(two days after surgery)
- the cost of hospitalization(the time of hospitalization， an average of 7 days)