NCT01774084已完成4 期
Insulin Sensitivity and Beta Cell Function After Carbohydrate Loading in Hip Replacement Surgery: A Randomised Doubled-blinded Control Study
适应症
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 23
- 试验地点
- 4
- 主要终点
- Change in Insulin Sensitivity
研究概览
简要总结
The purpose of this study is to determine whether preload of carbohydrate or water before elective hip replacement improve insulin sensitivity and or beta cell function in human.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Elective hip replacement
排除标准
- •Known diabetes mellitus
- •Kidney failure (creatinine clearance <40 ml/min
- •Liver failure (aspartate and alanine aminotransferases x 2 above reference)
- •Hb <110 g/l
- •Ongoing severe bacterial or viral infection
- •Malignancies
- •Psychiatric disease
结局指标
主要结局
Change in Insulin Sensitivity
时间窗: Morning before surgery and up to two days after surgery
Insulin sensitivity is measured by euglycemic hyperinsulinemic clamp
次要结局
- Change in Beta Cell Function(Morning before surgery and up to two days after surgery)
研究者
Thomas Nystrom
MD
Karolinska Institutet
研究点 (4)
Loading locations...
相似试验
终止
不适用
Insulin Sensitivity and Metabolism Before and After Treatment in Patients With HypothyroidismHypothyroidismNCT00770016University of Aarhus
招募中
不适用
Pre-diabetes in Subject With Impaired Fasting Glucose (IFG) and Impaired Glucose Tolerance (IGT)Impaired Glucose Tolerance (IGT)Impaired Fasting Glucose (IFG)Diabetes Mellitus, Type 2NCT02969798The University of Texas Health Science Center at San Antonio700
已完成
不适用
Insulin Sensitivity and Substrate Metabolism Before and After Treatment in Patients With Growth Hormone DeficiencyGrowth Hormone DeficiencyNCT00646815University of Aarhus24
已完成
不适用
DRIVE - Perioperative PeriodSurgical Procedure, UnspecifiedDiabetes MellitusNCT04033705Portsmouth Hospitals NHS Trust28
Unknown
不适用
C-peptide Correlation With Microvascular Complications in T1DMC-peptideDiabetes ComplicationsType 1 DiabetesNCT04474535National and Kapodistrian University of Athens200