Effects of buttermilk with or without lutein-enriched egg yolk on the serum LDL-cholesterol concentration of slightly hypercholesterolemic volunteers - buttermilk and cholesterol

niversiteit Maastricht0 个研究点目标入组 120 人开始时间: 待定最近更新: 2024年5月6日

适应症

试验速览

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•Subjects are asked to fill out a general health questionnaire in between the first and second screening visit. Only healthy subjects will be included. Obviously, the remark healthy only concerns the aspects checked for in the in and exclusion criteria. The inclusion criteria are:
•aged between 18 and 70 years
•fasting serum total cholesterol between 5.5 - 8.0 mmol/L
•fasting plasma glucose <7.0 mmol/L
•BMI between 25 - 30 kg/m2
•non-smoking
•willingness to abstain for the duration of the study from egg consumption

•unstable body weight (weight gain or loss >3 kg in the past 3 months)
•allergic for eggs or egg-rich products
•allergic or intolerant for cow-milk (lactose) based products
•indication for treatment with cholesterol-lowering drugs according to the Dutch Cholesterol Consensus
•use of medication or a diet known to affect serum lipid or glucose metabolism
•active cardiovascular disease (for instance congestive heart failure) or recent (<6 months) event, such as acute myocardial infarction or cerebro-vascular accident
•not willing to stop the consumption of vitamin supplements, fish oil capsules or products rich in plant stanol or sterol esters 3 weeks before the start of the study
•men: consumption of >21 alcohol consumptions a week
•women: consumption of >14 alcohol consumptions a week
•abuse of drugs
•pregnant or breastfeeding women
•participation in another biomedical study within 1 month prior to the screening visit
•having donated blood (as blood donor) within 1 month prior to the screening visit or planning to do so during the study
•impossible or difficult venipuncture as evidenced during the screening visits

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