The Effects of High-intensity Interval Training on Mental Health and Inflammation
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 60
- 主要终点
- Change in concentration of circulating proinflammatory cytokines (Interleukin-6, Interleukin-1 beta, Tumour necrosis factor alpha) from baseline to post-intervention
研究概览
简要总结
The present study investigated the effects of high-intensity interval exercise training and placebo-exercise on mental health and inflammation using a randomized control trial. The study also examined how anxiety symptoms prior to high-intensity interval training may influence improvements in fitness. Inactive young adults underwent nine weeks of either high-intensity interval training or their regular routine. Questionnaires, a blood draw and a maximal exercise test were conducted the week before and week after the intervention. It was hypothesized those who underwent high-intensity interval training would experience greater reductions in their depression, anxiety, and inflammation than those who were in the placebo control group. It was also hypothesized those who had high anxiety symptoms at the start of high-intensity interval training would experience smaller improvements in fitness than those who had low anxiety symptoms.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 30 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Full-time student at McMaster University
- •Speak, read and understand English
排除标准
- •Exercising for more than 150 minutes of moderate-to-vigorous physical activity per week
研究组 & 干预措施
High-intensity interval training
Three sessions of high-intensity interval training per week for nine weeks. Following a three minute warm up, a session contained twenty minutes of alternating between a sprint (80% of maximum workload, 90-95% of maximum heart rate) and active rest (30% of maximum workload) at a one minute to one minute ratio. Every session ended with a two and a half minute cool down.
干预措施: Exercise (Behavioral)
Placebo exercise group
No changes in physical activity behaviour occurred (already engaging in less than 150 minutes per week, instructed to maintain their current inactivity). They were told they needed to stay inactive since they were part of an 'acute' exercise group, aiming to see how long the effects of their baseline maximal exercise test would last. Thus, the cover story gave them the impression they were also in an exercise group, as oppose to a non-exercise control group.
干预措施: Placebo (Other)
结局指标
主要结局
Change in concentration of circulating proinflammatory cytokines (Interleukin-6, Interleukin-1 beta, Tumour necrosis factor alpha) from baseline to post-intervention
时间窗: 11 weeks
Picogram measured from venous blood sample
Change in mental illness symptoms (anxiety, depression) from baseline to post-intervention
时间窗: 11 weeks
The 21-items of the Beck Anxiety Inventory (Beck, Brown, Epstein \& Steer, 1998) are summed to produce a total score from 0-63, with a higher score reflecting more severe anxiety symptoms. The 21-items of the Beck Depression Inventory (Beck, Steer, \& Brown, 1996) are summed to produce a total score from 0-63, with a higher score reflecting more severe depressive symptoms.
Change in cardiorespiratory fitness from baseline to post-intervention
时间窗: 11 weeks
VO2peak test (ml/min/kg)
次要结局
未报告次要终点
研究者
Jennifer Heisz
Associate Professor
McMaster University