Effects of Blood Flow Restriction Training on Pain, Function, Disability, Quality of Life, and Common Extensor Tendon Thickness and Echogenicity in Patients With Lateral Epicondylitis: A Prospective Randomized Controlled Trial

Lateral epicondylitis (LE) is a common musculoskeletal disorder caused by repetitive overuse of the forearm extensor muscles. It is characterized by pain over the lateral epicondyle of the humerus, which may radiate to the surrounding tissues at the origin of the wrist extensor tendons. LE is one of the most frequent causes of lateral elbow pain, with a reported prevalence of approximately 1-3% in the general population. Although numerous conservative and invasive treatment modalities have been described, no universally accepted treatment algorithm currently exists. Among conservative interventions, exercise-based rehabilitation is considered a cornerstone of management because it improves tendon load tolerance, increases muscle strength, and facilitates functional recovery.

Although no consensus has been reached regarding the optimal exercise protocol, recent research has focused on interventions that enhance the adaptation of the common extensor tendon to mechanical loading. In particular, exercise programs incorporating eccentric contractions have demonstrated superior clinical outcomes compared with several other exercise approaches and are therefore widely recommended. Furthermore, regular exercise has been shown to improve tendon mechanical properties by increasing collagen synthesis as well as collagen fiber number and diameter.

To achieve meaningful improvements in muscle strength and hypertrophy, resistance exercise is generally recommended at loads of at least 70% of the one-repetition maximum (1RM). However, such loading is often poorly tolerated by individuals experiencing pain, muscle weakness, or muscle atrophy during the early stages of musculoskeletal rehabilitation. Consequently, high-intensity resistance exercise may exacerbate symptoms and reduce treatment adherence.

Blood flow restriction training (BFRT) has recently emerged as an alternative rehabilitation strategy that promotes neuromuscular adaptations while using low mechanical loads. BFRT involves the application of a pneumatic cuff, tourniquet, or elastic band around the proximal portion of an extremity to partially restrict arterial inflow while substantially reducing venous return, thereby creating localized metabolic and hemodynamic stress during exercise.

In BFRT, resistance exercises are typically performed at 20-30% of the one-repetition maximum (1RM). Despite the low training intensity, accumulating evidence indicates that BFRT can produce gains in muscle strength and hypertrophy comparable to those achieved with conventional high-intensity resistance training.