Relationship Between Abnormalities of Desmin Cytoskeleton, Mitochondrial Activity and Expression of Ubiquitin in Aspect of Pathogenesis of Heart Failure and Prognosis.

Ministry of Scientific Research and Information Technology, Poland2 个研究点分布在 1 个国家目标入组 60 人开始时间: 2009年1月1日最近更新: 2009年1月9日

适应症

试验速览

阶段: 不适用
发起方
入组人数: 60
试验地点: 2
主要终点: all cause mortality

研究概览研究设计入排标准结局指标研究者研究点记录与标识符相似试验

研究概览

简要总结

The purpose of this study is evaluation of expression of desmin in cardiomyocytes of patients with idiopathic dilated cardiomyopathy. Analysis of relationship between desmin expression and activities of mitochondrium and expression of ubiquitin.

研究设计

研究类型: Interventional
干预模型: Parallel
主要目的: Diagnostic
盲法: None

入排标准

年龄范围: 18 Years 至 65 Years（Adult, Older Adult）
性别: All
接受健康志愿者: 否

入选标准

•idiopatic dilated cardiomyopathy, NYHA I, II, III, IV
•dilated left ventricle
•ejection fraction below 45%

排除标准

•diabetes mellitus
•kidney failure (GFR < 30, creatinine below 2,5 mg/dl

结局指标

主要结局

all cause mortality

时间窗: one year

次要结局

qualitative differences in desmin expression in cardiomyocytes of patient with heart failure(one year)

研究者

发起方

Ministry of Scientific Research and Information Technology, Poland

申办方类型

Other Gov

研究点 (2)

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