Optimizing Long-term Survival in Organ Transplantation: From Physiopathology to Optimized Patient Management
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 430
- 试验地点
- 7
- 主要终点
- Survival of the graft
研究概览
简要总结
Increased indications for transplantation continue to worsen the shortage of organs and need the extension of graft sampling criteria and the search for new potential sources of organs. Despite undeniable success in the short term, due to major advances in surgery, medicine and research, transplant recipients continue to face the risk of chronic rejection and long-term complications.
The University Hospital Federation "FHU SUPORT" was created to optimize the chances of success of the organ transplant and improve the quality of life of the transplanted patient. FHU SUPORT 's ambition is based on a translational strategy that presents two priority areas:
Axis 1: Optimization, evaluation, conditioning of the donor, graft, recipient Axis 2: Personalized follow-up of the transplanted patient in the short and long term Identifying factors for long-term graft and patient survival through translational research from a common cohort and biological collection will predict transplant rejection, prolong graft function, or improve the patient's care.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Male or female over 18 (no age limit)
- •affiliated to a social security organization
- •Recipient (s) of a kidney, liver or heart transplant
- •followed by at least one of the FHU SUPORT centers (Tours, Poitiers, Limoges, Rennes)
- •having given informed consent to participate in the cohort.
排除标准
- •Patient unable to understand the information given by the investigator
- •People under the protection of justice
研究组 & 干预措施
blood, bile and urine samples
blood and urine samples at D0,D1, D3 D7, D14, M1, M3, M6 and M12
干预措施: blood and urine samples (Other)
结局指标
主要结局
Survival of the graft
时间窗: 12 months
次要结局
未报告次要终点