Luftibus in the School: a Population-based Study of Respiratory Symptoms, Lung Function and Air Pollution.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 3,500
- 试验地点
- 1
- 主要终点
- Parent-reported respiratory symptoms
研究概览
简要总结
This study assessed the respiratory health of schoolchildren from the canton of Zurich by combining self-reported information on respiratory symptoms with lung function test results and air pollution measurements.
Luftibus in the school (LUIS) is a population-based study conducted in the canton of Zurich, Switzerland. Between the years 2013 and 2016 a bus with equipment for lung function testing and air pollution measurement visited numerous schools across the canton Zurich. The parents of the schoolchildren filled in a questionnaire with validated questions on upper and lower respiratory symptoms, trigger factors, diagnosis, treatment of respiratory symptoms, health behavior and environmental factors. The children were interviewed using a shorter questionnaire. Fieldworkers measured lung function (spirometry and double tracer gas single-breath washout) and an airway inflammation test (fractional exhaled nitric oxide) in the bus. The recruited population included 3500 schoolchildren aged 6 to 16 years from the canton of Zurich.
Respiratory symptoms and their influence on physical activity and sleep have a strong impact on children's quality of life and school performance. The results of this study will provide new insights on schoolchildren's respiratory health that may help to establish new recommendations and influence policy makers' decisions.
详细描述
Background:
Few population-based studies have recently investigated the epidemiology of childhood respiratory symptoms in Switzerland.
Objectives:
The Luftibus in the school study was setup to assess the respiratory health of schoolchildren from the canton of Zurich and to investigate relationships between respiratory symptoms, lung function and air pollution.
Methods:
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 6 Years 至 16 Years（Child）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Schoolchildren living in the canton of Zürich
- •Age range 6 to 16 years
- •Parental consent to participate
排除标准
- 未提供
结局指标
主要结局
Parent-reported respiratory symptoms
时间窗: At baseline
Prevalence of upper and lower respiratory tract symptoms including wheeze, cough, rhinitis and snoring, reported using parent questionnaires.
Lung function measurements: Spirometry, forced expiratory volume in 1 second z-scores
时间窗: At baseline
Forced expiratory volume in 1 second (FEV1) z-scores calculated based on Global Lung Function Initiative (GLI) reference values.
Lung function measurements: Single-breath washout
时间窗: At baseline
Slope from the tidal (alveolar) phase III (SIII) from double-tracer gas single-breath washout test curves.
Airway inflammation
时间窗: At baseline
Airway inflammation measured by levels of fractional concentration of exhaled nitric oxide.
Self-reported respiratory symptoms
时间窗: At baseline
Prevalence of upper and lower respiratory tract symptoms including wheeze, cough, rhinitis and snoring, reported using participant questionnaires.
Lung function measurements: Spirometry, forced vital capacity z-scores
时间窗: At baseline
Forced vital capacity (FVC) z-scores calculated based on Global Lung Function Initiative (GLI) reference values.
次要结局
- Lung function measurements: Single-breath washout(One year after baseline)
- Parent-reported respiratory symptoms(One year after baseline)
- Lung function measurements: Spirometry, forced expiratory volume in 1 second z-scores(One year after baseline)
- Lung function measurements: Spirometry, forced vital capacity z-scores(One year after baseline)
- Airway inflammation(One year after baseline)
- Self-reported respiratory symptoms(One year after baseline)