Influence of CYP2C9 gene polymorphisms on the analgesic effect of piroxicam in patients with osteoarthritis of knee

Sri Devaraj Urs Academy of Higher Education and Research0 个研究点目标入组 0 人开始时间: 待定最近更新: 2021年11月24日

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•1.Patients of either gender, aged between 40-70years
•2.Body mass index (BMI) of 25-30
•3.Patients with symptomatic idiopathic OA
•4.Knee osteoarthritis of mild to moderate type
•5.Radiological evidence of OA of involved joint
•6.Morning stiffness of less than 30 minutes duration with crepitus on motion
•7.Patients who were on NSAIDs including piroxicam and should have discontinued the drug for a period of two weeks before recruitment

•1.Patients with history of surgery or acute trauma to the knee joint in the past 6months
•2.Patients with history of peptic ulcer, gastrointestinal bleeding, psychiatric illness and bronchial asthma
•3.Patients with history of acute inflammatory arthritis, pseudo gout or severe osteoporosis
•4.Patients with history of allergy to study drug
•5.Patients with deranged hepatic and renal parameters
•6.Pregnant and lactating women
•7.Patients who use other measures for pain relief like massage, acupuncture, hydrotherapy, homeopathy, chiropractic manipulation, transcutaneous electrical nerve stimulation, use of knee braces, shoe wedges, application of creams containing capsaicin, self medication with analgesics and nutritional supplements like glucosamine and chondroitin sulfate during the past 4 weeks and study period.
•8.Patients with uncontrolled diabetes mellitus and hypertension

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