Effect of Continuous Evidence-based Feed Back to Increase Appropriate Use of Antibiotics
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 8,053
- 试验地点
- 1
- 主要终点
- 20% difference in use of antibiotics in patients with suspected Acute bronchitis
研究概览
简要总结
Inappropriate use of antibiotics in primary care is associated with Development of antibiotic resistant strains. As part of a quality improvement program carried out in primary care in Uruguay, Argentina, Paraguay and Bolivia, a cluster randomized control trial was performed. The aim of the study was to assess whether the use of continuous evidence-based feedback about management of respiratory tract infections could decrease use of antibiotics in Acute bronchitis, common cold and acute otitis media.
详细描述
Excessive and inappropriate use of antibiotics is one of the most important reasons for development of resistant bacteria.
One of the key strategies to curb the development of antibiotic resistance is to promote intervention at primary care level as more than 90% of antibiotics are prescribed by general practitioners - especially in patients suffering from respiratory tract infections.
The main bacteria causing respiratory tract infections are S. pneumoniae y Haemophilus influenzae. The first one is associated with a significant increase in morbidity and mortality in Latin America.
Approximately 80% of respiratory tract infections have a viral cause, are harmless and self-limiting and in most cases patients recover without specific treatment. Antibiotic treatment is superfluous and in some cases even harmful because of side effects.
Infections caused by resistant bacteria leads to increased mortality, prolonged hospital stay and social collateral damage. Therefore, in 2013 the World Economic Forum pointed out antibiotic resistance as one of the three most important threats to economic and social development.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Health Services Research
- 盲法
- None
入排标准
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •General practitioners working in primary care
- •Patients with suspected respiratory tract infection
排除标准
- •Patients that have already started an antibiotic
结局指标
主要结局
20% difference in use of antibiotics in patients with suspected Acute bronchitis
时间窗: 3 months
次要结局
- 20% difference in the use of antibiotics in suspected acute otitis media(3 months)
研究者
Gloria Cristina Cordoba
MD-MPH
University of Copenhagen