An Exploratory Study of Biomarkers in the Endometrial Fluid, Tissue, and Follicular Fluid of Moderate/Severe Endometriosis Patients: a Prospective Study
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 90
- 试验地点
- 1
- 主要终点
- Relative expression levels (e.g., fold change, normalized intensity, or concentration in pg/mL/ng/mL depending on biomarker assay)
研究概览
简要总结
This study aims to explore biomarkers in the endometrial fluid and tissue of women with moderate to severe endometriosis, with a specific focus on those involved in pre-receptive endometrium and embryo implantation. This research has the potential to uncover diagnostic indicators of impaired pre-receptive endometrium, examine pathophysiological pathways, and identify future targets for therapeutic intervention. Ultimately, the findings may contribute to more personalized fertility treatments, offering new hope for women struggling with endometriosis-related infertility.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Age 18-40 years old
- •Diagnosed with moderate/severe endometriosis by ultrasound or laparoscopy (patient group)
- •Regular menstrual cycles 28-35 days
- •Speak English or Swedish and agree to participate in the study
排除标准
- •Pregnancy or lactation in the last 3 months
- •Uterine anomalies
- •Pelvic inflammatory disease, endometritis, STD
- •Gynaecological cancers or other malignancies in the patient's history
- •Smoking (more than 10 cigarettes per day) or alcohol abuse
- •Immunosuppressing medicines
- •Major abdominal or pelvic surgery in the last 3 months
- •A specific genetic disease that is diagnosed before PGT in women undergoing treatment
结局指标
主要结局
Relative expression levels (e.g., fold change, normalized intensity, or concentration in pg/mL/ng/mL depending on biomarker assay)
时间窗: 2 years
Evaluation of the expression levels of selected biomarkers in endometrial fluid samples from patients with moderate to severe endometriosis compared to healthy controls.
Percentage of blastoids successfully implanted in vitro (% implantation rate)
时间窗: 2 years
Evaluation of the implantation efficiency of blastoids in vitro (endometrial organoids) under controlled laboratory conditions.
次要结局
- Relative expression levels (e.g., concentration in pg/mL, ng/mL, or fold change depending on assay)(2 years)