Comparison of effects of cisatracurium and atracurium upon Tryptase, IgE levels and Absolute eosinophil counts in adult patients undergoing general anesthesia for elective surgery.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- Patients tryptase levels,IgE levels, absolute eosinophil count, hemodynamic parameters (heart rate and SBP/DBP), cilinical side effects ( flushing of skin, rashes, hypotension, tachycardia, bronchospasm, anaphylaxis, arrhythmias)
研究概览
简要总结
This is a randomized prospective observational study in which comparison will be done on effects of cisatracurium and atracurium upon trypase levels , Ig E levels and absolute eosinophil counts in adult patients undergoing general anesthesia for elective surgery in Dr RML hospital New Delhi . The outcome measures will be tryptase levels, IgE levels, absolute eosinophil count , hemodynamic parameters and clinical side effects profile of the patients before induction, one and two hours after giving first dose of study drug and at the time of any side effects if any.
研究设计
- 研究类型
- Interventional
- 分配方式
- Computer generated randomization
- 盲法
- Participant and Outcome Assessor Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •Consenting adult patients with ASA Grade 1/2 and modified Mallampati grade 1/2.
排除标准
- •Patients with anticipated difficult airway.
- •Patients with peripheral neuropathy, diabetes mellitus, neuromuscular disorders and myopathies.
- •Patients on antibiotics (e.g., aminoglycosides, tetracyclins, bacitracin, lincomycin, clindamycin, colistin).
- •Patients on drugs like Magnesium sulphate, lithium, procainamide and quinidine.
- •Patients with history of atopy and asthma.
- •Patients with known allergy to any of the drugs involved in study.
- •pregnant patients.
结局指标
主要结局
Patients tryptase levels,IgE levels, absolute eosinophil count, hemodynamic parameters (heart rate and SBP/DBP), cilinical side effects ( flushing of skin, rashes, hypotension, tachycardia, bronchospasm, anaphylaxis, arrhythmias)
时间窗: Blood samples will be taken before induction , one and two hour after giving first dose of study drug and additional sample if and when any side effects occurs.
次要结局
未报告次要终点