A clinical study to know the differences in the maximum response produced by the two drugs of two drugs (Atracurium and Cisatracurium) in terms of haemodynamic effects and pharmacological actions in the patients who are undergoing surgeries under General Anesthesia.

Phase 2

Completed

• Conditions: Medical and Surgical,

• Registration Number: CTRI/2018/11/016361
• Lead Sponsor: DrAswani Baskaran

Brief Summary

This study is a randomized  double blinded parallel group trial comparing the efficacy of atracurium and cisatracurium in patients undergoing surgeries under general anesthesia. The loading dose (2\*ED95) of ATRACURIUM is 0.5mg/kg iv and maintenance dose of ATRACURIUM is 0.1mg/kg iv.The loading dose92\*ED95) of Cistracurium is 0.1mg/kg iv and maintenance dose of CISATRACURIUM is 0.02mg/kg iv. The study is conducted for a period of one year in Chettinad Hospital and research Institute. The primary outcome of the study is onset and duration of action of the neuromuscular blocking drug. The secondary outcomes are the hemodynamic variability, histamine release and condition on intubation.

Detailed Description

Not available

Study Timeline

• Study Start: 2018-11-26
• Study Completion: 2019-07-31
• Last Update Posted: 2020-01-08

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

ASA I ASA II ASAIII Both elective and emergency procedures.

Exclusion Criteria

ASAIV Pregnant patients Patients with Bronchial asthma Patients with history of cardiovascular disorders Patients with history of hepatic and renal disorders Patients on medications known to interact with neuromuscular blocking drugs.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Onset and duration of action of neuromuscular blocking drug	Onset of action : time from the administration of drug till TOF0. Duration of action is time from administration of drug till TOF1

Secondary Outcome Measures

Name	Time	Method
Haemodynamic variability ( HR SBP DBP SPO2 ) Histamine release laryngoscopy	10min 20min 30min 45min 60min 75min 90min 105min 120min

Trial Locations

Locations (1)

Chettinad Hospital and Research Institute; 🇮🇳 Kancheepuram, TAMIL NADU, India

Chettinad Hospital and Research Institute

🇮🇳Kancheepuram, TAMIL NADU, India

Dr Aswani Baskaran

Principal investigator

9677241756

swanbkn@gmail.com