Hämeenlinna Metabolic Syndrome Research Program (HMS): Effects of Dietary Cold-pressed Turnip Rapeseed Oil and Milk Fat on Serum Lipids, Oxidized LDL, Arterial Elasticity and Platelet Function
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 43
- 试验地点
- 8
- 主要终点
- Circulating lipids
研究概览
简要总结
In this study, the effects of dietary intake of cold-pressed turnip rapeseed oil (CTPRO) and milk fat are compared in men with metabolic syndrome having already participated in HMS-02 study.
详细描述
This open and balanced cross-over study consists of two dietary treatment phases (either Virgino (R) CTPRO or butter) for 6 to 8 weeks. They are separated from each other with an eight-week washout period. At the end of both periods and 12-hour fasting an oral glucose-fat tolerance test is carried out. Except glucose, the test consists cream (after the butter phase) and CTPRO (after the CTPRO phase).
Otherwise, the subjects (n=43) are asked to maintain their normal dietary habits.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 31 Years 至 66 Years（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 否
入选标准
- •43 men with metabolic syndrome having already participated in the HMS-02 Study
- •Willing to participate in a demanding dietary study
排除标准
- 未提供
结局指标
主要结局
Circulating lipids
时间窗: 6 to 8 weeks
At the end of both 6- to 8-week dietary periods, fasting values of circulating lipids including oxidized LDL are determined
Platelet function
时间窗: 6 to 8 weeks
At the end of both 6- to 8-week dietary periods, platelet function is determined
Glucose tolerance
时间窗: 5 hours
During a 5-hour oral glucose-fat tolerance test the area under curve of plasma glucose and insulin concentration is determined
次要结局
- Arterial elasticity(6 to 8 weeks)
- Serum triglyceride AUC(5 hours)
- Platelet function(5 hours)