Comparison of the Effects of Melatonin and Lymphatic Drainage Massage on Pain, Edema, and Mouth Opening Following Impacted Third Molar Extraction
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- melatonin effect on edema: Postoperative edema will be measured preoperatively and on the 3rd and 7th days. Distances between the gonion-lateral canthus and tragus-labial commissure will be measured and recorded with a thread.
研究概览
简要总结
Lymphatic drainage massage is an important practice, especially for reducing edema. It is a very gentle, monotonous, slow, rhythmic massage applied to the skin surface. It accelerates the flow of lymph fluid and provides comfort by minimizing swelling. Lymphatic drainage massage, which is frequently used after impacted third molar surgery, helps reduce edema and increases patient comfort during the postoperative period.
Melatonin, a hormone produced by the pineal gland, is a neurochemical substance that works in harmony with the body's natural rhythm. In addition to the brain, it is found in the retina, bone marrow, intestines, skin, and various blood cells. Conditions such as insomnia or jet lag may benefit from melatonin supplements. Besides contributing to sleep quality, melatonin may also assist in regulating the immune system, body temperature, blood pressure, and cortisol hormone levels.
详细描述
Another important function of melatonin is that it is a very powerful free radical scavenger. Melatonin can neutralize both reactive oxygen species and reactive nitrogen species. It is also known to capture highly toxic hydroxyl radicals, peroxynitrite anions, and peroxyl radicals. In some cases, melatonin inhibits nitric oxide synthase, a prooxidant enzyme. Additionally, it stimulates the mRNA levels of superoxide dismutase enzyme and is known to activate glutathione peroxidase, glutathione reductase, and glucose-6-phosphate dehydrogenase. After reacting with the hydroxyl free radical (OH•), melatonin transforms into an indolyl cation radical, which is noted to capture the superoxide radical (O2 · -) in the environment and exhibit antioxidant activity. Due to this powerful antioxidant property, its effects on pain and edema have been investigated in some studies. In these studies, pre-op/post-op melatonin application has been shown to reduce postoperative pain and accelerate sensory healing due to melatonin's antioxidant effects.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 55 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patients need for removal surgery of impacted third molars.
- •Patients without systemic diseases.
排除标准
- •Presence of systemic diseases affecting general health.
- •Presence of a malignant disease in the head and neck region.
- •Patients with any bleeding disorders.
- •Patients with cardiovascular diseases or those undergoing anticoagulant or antiplatelet therapy.
结局指标
主要结局
melatonin effect on edema: Postoperative edema will be measured preoperatively and on the 3rd and 7th days. Distances between the gonion-lateral canthus and tragus-labial commissure will be measured and recorded with a thread.
时间窗: postoperative 7 days
during the post operative periods patients receive melatonin pill until 7 days
次要结局
- Lymphatic drainage massage effect on edema: Postoperative edema will be measured preoperatively and on the 3rd and 7th days. Distances between the gonion-lateral canthus and tragus-labial commissure will be measured and recorded with a thread.(postoperative 7 days)