Sustained Effects of Blueberry Polyphenols on Vascular Function in Healthy Individuals
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 45
- 试验地点
- 2
- 主要终点
- Endothelial function
研究概览
简要总结
Diets rich in fruits and vegetables have been linked to favorable cardiovascular outcomes in epidemiological studies.
Dietary intervention studies with certain micronutrients have shown promising effects on surrogate parameters of vascular risk including blood pressure, endothelial function and cholesterol levels. Wild blueberries have gained attention due to their high content of phytochemicals and particularly anthocyanins. Whether wild blueberries can improve vascular function and health when given over relevant time periods and in relevant populations is not known. Therefore, it is the overall hypothesis of the study proposal that chronic consumption of wild blueberries can improve endothelial function, a prognostically validated surrogate of cardiovascular risk.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •healthy male subjects without clinical signs or symptoms of cardiovascular disease
- •18-70 years
排除标准
- •cardiovascular disease
- •acute inflammation
- •cardiac arrhythmia
- •renal failure
- •heart failure (NYHA II-IV)
- •diabetes mellitus
- •C- reactive protein > 1mg/dl
- •malignant disease
结局指标
主要结局
Endothelial function
时间窗: baseline and 1 month
Determination of endothelial function by Flow mediated dilation (FMD) 0 and 2 hours postconsumption
次要结局
- Pulse wave velocity(baseline and 1 month)
- Blood lipids(baseline and 1 month)
- Blood pressure(baseline and 1 month)
研究者
Klinik für Kardiologie, Pneumologie und Angiologie
Dr. Ana Rodriguez Mateos
Heinrich-Heine University, Duesseldorf