NCT01505699已完成不适用
Micro RNA Expression Analysis in B-Lineage Adult Acute Lymphoblastic Leukemia From ALL Trial, E2993, Including Patients With Various Cytogenetic and Molecular Abnormalities
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 186
- 主要终点
- Comprehensive view of microRNA expression by cytogenetic subgroup
研究概览
简要总结
RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help doctors identify and learn more about biomarkers related to cancer.
PURPOSE: This research study is studying biomarkers in samples from patients with acute lymphoblastic leukemia enrolled on ECOG-2993 clinical trial.
详细描述
OBJECTIVES:
- To identify microRNAs that behave as oncogenes or as tumor suppressor genes in B-lineage acute lymphoblastic leukemia (ALL) in vitro and in vivo.
- To examine if single microRNA or signatures of microRNA correspond to different clinical outcomes in cytogenetically distinct B-ALL groups.
OUTLINE: RNA from archived samples are analyzed for microRNA expression profile in vitro and in vivo.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 15 Years 至 65 Years（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
Comprehensive view of microRNA expression by cytogenetic subgroup
时间窗: 1 year
MicroRNA expression in relation to clinical outcome
时间窗: 1 year
Differential microRNA expression between normal B-cells and progenitors compared to B-ALL
时间窗: 1 year
次要结局
未报告次要终点
研究者
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