NCT01786616已完成不适用
Polymorphism of beta2-adrenoceptor and Regular Use of Formoterol in Asthma: Preliminary Results
Catholic University, Italy1 个研究点 分布在 1 个国家目标入组 30 人开始时间: 2005年1月最近更新:
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Peak Expiratory Flow (PEF) variability
研究概览
简要总结
Polymorphism at codon 16 of the beta2-adrenoceptor (beta2-AR) affects the responsiveness to salmeterol in asthmatics. Data concerning formoterol are more controversial in literature. The aim of this study was to verify whether homozygote for arginine-16 (ArgArg16) and homozygote for glycine-16 (GlyGly16) genotypes differently influence the long-term responsiveness to formoterol.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Mild to moderate asthma
- •Stable clinical conditions
排除标准
- •Current therapy with oral steroids
- •Exacerbations within the past 3 months
研究组 & 干预措施
Formoterol
12 mcg BID for four weeks
干预措施: Formoterol (Drug)
结局指标
主要结局
Peak Expiratory Flow (PEF) variability
时间窗: PEF has been monitorized during the 4-week treatment period
次要结局
- Forced Expiratory Volume in 1 sec (FEV1) slope of the dose-response curve to salbutamol(At the end of the 4-week treatment period)
研究者
Leonello Fuso
Researcher
Catholic University, Italy
研究点 (1)
Loading locations...
相似试验
已完成
不适用
How Different Beta-2 Receptor Genotypes Affect an Asthmatic's Response to Regular Salmeterol TreatmentAsthmaNCT00595361Brigham and Women's Hospital30
已完成
不适用
Beta-2 Polymorphisms and Beta Receptor SelectivityHeart FailureNCT00214318University of Wisconsin, Madison25
已完成
不适用
Brain Receptors in Sympathetic Nervous System RegulationHealthyNCT00029627National Institute of Mental Health (NIMH)200
已完成
不适用
Vascular Response to Isoproterenol and β2 Adrenergic Receptor PolymorphismsCoronary DiseaseNCT00226551Hadassah Medical Organization100
招募中
不适用
The study of beta-2 adrenergic receptor polymorphism in healthy adult.healthy adultJPRN-UMIN000005858Kagoshima university100