Acute Effects of Light and Dark Roasted Coffee on Glucose Tolerance: A Randomized, Controlled Crossover Trial in Healthy Volunteers
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 11
- 试验地点
- 2
- 主要终点
- Plasma glucose Area Under the Curve (Glucose AUC)
研究概览
简要总结
Chlorogenic acid (CGA) in coffee may lower the postprandial glucose response. CGA is destroyed by dark roasting. In a controlled crossover trial, 11 healthy fasted volunteers consumed 300 mL of either light (LIR) or dark (DAR) roasted coffee, or water, followed 30 min later by a 75-g oral glucose tolerance test (OGTT). Plasma glukose and insulin, appetite, and plasma and urine metabolic profiles will be analysed. The primary aim is to investigate whether roasting affects the postprandial glucose area under the curve (AUC).
详细描述
Epidemiologic evidence suggests that coffee consumption is associated with a lower risk of type 2 diabetes. Coffee contains caffeine and several other components that may modulate glucose regulation. The chlorogenic acids (CGA) in coffee have been indicated as constituents that may help to normalize the acute glucose response after a carbohydrate challenge. The aim of this study was to investigate whether two coffee beverages that differ in CGA content due to different roasting degrees will affect glucose regulation differently.
In a controlled crossover trial, 11 healthy fasted volunteers consumed 300 mL of either light roasted (LIR) or dark roasted (DAR) coffee, or water, followed 30 min later by a 75-g oral glucose tolerance test (OGTT). Blood samples were drawn at baseline, 30, 60 and 120 min. Differences in glucose and insulin responses and insulin sensitivity index (ISI) were analyzed. The CGA and caffeine contents in the coffees were analyzed using UPLC-MS/MS.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Prevention
- 盲法
- Double (Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Body mass index (BMI) of 18.0-30.0 kg/m2 and with no known diseases
排除标准
- •systemic infections,
- •psychiatric or metabolic disorders,
- •known food allergies or intolerances related to the products used in the study (e.g. dairy or gluten),
- •ongoing or former drug abuse,
- •high intake of alcohol (defined as a weekly intake of >7 units for women and > 14 units for men),
- •pregnancy or ongoing planning of pregnancy,
- •vegetarianism or veganism,
- •participation in other scientific studies during the study period, and
- •blood donation during - or in the month leading up to - the study period
结局指标
主要结局
Plasma glucose Area Under the Curve (Glucose AUC)
时间窗: 0-120 min
The area under the plasma glucose concentration curve was calculated from 0-120min after 75g glucose was ingested.
次要结局
- Plasma glucose concentrations(30, 60 and120 min)
- Serum Insulin Area Under the Curve(0-120 min)
- ISI(0-120)(0-120min)
- Metabolic profile in plasma(0-24 hours)
- Serum insulin concentrations(30, 60 and120 min)
- Metabolic profile in urine(0-24 hours)
研究者
Professor Lars Ove Dragsted
Professor
University of Copenhagen