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临床试验/NCT03094962
NCT03094962已完成不适用

Development of Parametric Musculoskeletal Models to Investigate the Anatomy and the Function of the PIP

University of Southampton2 个研究点 分布在 1 个国家目标入组 10 人开始时间: 2015年1月21日最近更新:
适应症
干预措施

试验速览

阶段
不适用
状态
已完成
入组人数
10
试验地点
2
主要终点
Capturing hand kinematics using Vicon optical motion capture

研究概览

简要总结

The proximal interphalangeal (PIP) joint is the second joint in the finger from the finger tip. The outcome following replacement surgery of this joint is considered unsatisfactory. In order to improve these outcomes, it would be helpful to understand the geometry of the joint, how it moves and the forces that are involved. This can be achieved using computer models that model the bones and the soft tissues - musculoskeletal models. In order to make these models as representative as possible, they should be generated using anatomical data.

Data will initially be extracted from patients' existing magnetic resonance imaging (MRI) and computed tomography (CT) scans. This will enable the computer model to begin being constructed. In parallel to the model initialisation, anatomical and motion data of the PIP joint of healthy volunteers will be collected. The necessary data will be collected using CT and MRI scans, as well as optical motion tracking methods. These data will then be used to populate the musculoskeletal model.

Once the model is constructed, it will be used to simulate the motion of the joint and look at the effect of a simulated PIP joint replacement. This information should then provide insight as to how PIP joint replacements might be improved in future.

研究设计

研究类型
Interventional
分配方式
Na
干预模型
Single Group
主要目的
Basic Science
盲法
None

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • In general good health
  • University of Southampton members of staff
  • Over 18 years old and able to provide informed consent
  • No known problems relating to the PIP joint

排除标准

  • Volunteers involved in other studies concerned with the function and anatomy of the PIP joint which would have adverse effects on this study and/or the study in which they are currently involved.
  • Those undergoing treatment related to the PIP joint
  • No metallic object should be present in the scanner and therefore those with any implanted metallic devices, or other devices which may cause or be caused adverse effects (e.g. metal plate, pacemaker)

研究组 & 干预措施

Motion capture, MR scan, CT scan

Other

All volunteers will go through the same data collection process

干预措施: Motion capture (Other)

Motion capture, MR scan, CT scan

Other

All volunteers will go through the same data collection process

干预措施: MR scan (Diagnostic Test)

Motion capture, MR scan, CT scan

Other

All volunteers will go through the same data collection process

干预措施: CT scan (Diagnostic Test)

结局指标

主要结局

Capturing hand kinematics using Vicon optical motion capture

时间窗: 3 years

Capture hand kinematics of 10 healthy volunteers

Capturing images of the soft tissue in the hand using MR imaging

时间窗: 3 years

Capture MR images of the hand for same 10 healthy volunteers as Outcome 1

Capturing images of the bony structures in the hand using CT scanning

时间窗: 3 years

Capture CT images of the hand for same 10 healthy volunteers as Outcome 1

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Sponsor

研究点 (2)

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