The Efficacy of Hyaluronic Acid and Honey in Healing of Multiple Extraction Sockets of Primary Teeth Compared to Saline in a Group of Egyptian Children
试验速览
- 阶段
- 不适用
- 入组人数
- 39
- 主要终点
- Wound healing size in length and width
研究概览
简要总结
This study aims to evaluate the effect of hyaluronic acid and honey compared to saline in healing of multiple extraction sockets of primary teeth in a group of children aging from Two to Seven years old.
详细描述
A dental extraction is one of the most unpleasant experiences in children, especially for those who have undergone traumatic experiences, and this is likely to reduce future visits to the dental clinic if the treatment is not managed properly.
Alveolar osteitis is one of the most common complications following dental extraction. It is considered one of the most studied complications in dentistry, and many risk factors contribute to its occurrence including being a female, young age, tobacco use, difficult or traumatic extractions, pre-existing infection, and use of vasoconstrictor in local anesthesia. Alveolar osteitis occurs during the first three days following the day of extraction, so that the socket is devoid of the blood clot, resulting in the exposure of the bare alveolar bone.
Many medicines were and are still used in treating wounds, but they are somewhat expensive.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
盲法说明
Neither the operator nor the patients could be blinded due to the nature of the study, but the statistician will be blinded.
入排标准
- 年龄范围
- 2 Years 至 7 Years（Child）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •• Age: from Two to Seven years old age.
- •Both genders.
- •Children with badly decayed multiple primary teeth beyond repair.
- •Treated under general anesthesia.
排除标准
- •• History of systemic disease.
- •Allergy to honey.
- •Repeatedly used honey during the previous 6 month period.
研究组 & 干预措施
Hyaluronic acid.
1mm layer of hyaluronic acid on a piece of gauze will be applied directly to the sockets wound for 45 minutes at baseline and on the third & seventh day after extraction of teeth.
干预措施: Hyaluronic acid (Drug)
Hyaluronic acid.
1mm layer of hyaluronic acid on a piece of gauze will be applied directly to the sockets wound for 45 minutes at baseline and on the third & seventh day after extraction of teeth.
干预措施: honey (Dietary Supplement)
Honey
1mm layer of Honey on a piece of gauze will be applied directly to the sockets wound for 45 minutes at baseline and on the third & seventh day after extraction of teeth.
干预措施: Hyaluronic acid (Drug)
Honey
1mm layer of Honey on a piece of gauze will be applied directly to the sockets wound for 45 minutes at baseline and on the third & seventh day after extraction of teeth.
干预措施: honey (Dietary Supplement)
Saline
a piece of gauze moistened with normal saline will be applied directly to the sockets wound for 45 minutes at baseline and on the third & seventh day after extraction of teeth.
干预措施: Hyaluronic acid (Drug)
Saline
a piece of gauze moistened with normal saline will be applied directly to the sockets wound for 45 minutes at baseline and on the third & seventh day after extraction of teeth.
干预措施: honey (Dietary Supplement)
结局指标
主要结局
Wound healing size in length and width
时间窗: After one week will be calculated the size (lentgh and width) of socket
There is only one outcome (wound healing) • Multiple measurements (Digital caliper, color, palpation, presence of pus, gingival margin status). 1. Digital caliper: a device used to calculate the size of the socket (width and length) buccolingual in mesiodistal with measurement of mm. 2. Color: normal (pinkish gingiva) Up normal (reddish gingiva) 3. Palpation: if there is bleeding or not. 4. Presence of pus: yes or no 5. Gingival margin: epithelization (yes or no)
次要结局
未报告次要终点
研究者
Anas Rahima
Principal Investigator
Cairo University