ISRCTN29195046已完成未知
Mobilising vitamin D sequestered in adipose tissue in humans with Exercise (VitaDEx)
niversity of Bath0 个研究点目标入组 71 人开始时间: 2019年1月21日最近更新:
适应症
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 发起方
- 入组人数
- 71
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 性别
- All
入选标准
- •Group 1: 10-week RCT in overweight men and women
- •1. Aged 25-65 years
- •2. Fat Mass Index (FMI) determined using DEXA of 7.5-15 kg/m2 (?) and 11-21 kg/m2 (?).
- •3. Self-reported participation in no vigorous intensity physical activity and less than 150 minutes of moderate intensity activity per week AND an objectively assessed Physical Activity Level (PAL) less than 2.00 (total energy expenditure/resting energy expenditure)
- •4. Available during the winter months (October-March)
- •5. Non-smoker
- •Group 2: Lean comparator group
- •1. Aged 25-65 years
- •2. Fat Mass Index (FMI) determined using DEXA of 2-6 kg/m2 (?) and 4-9 kg/m2 (?).
- •3. Self-reported participation in either 150 minutes of moderate intensity or 75 minutes of vigorous intensity physical activity per week AND an objectively assessed Physical Activity Level (PAL) greater than 1.75
- •4. Available during the winter months (October-March)
- •5. Non-smoker
排除标准
- •Group 1: 10-week RCT in overweight men and women
- •1. Current or recent use of weight loss drugs
- •2. Any reported recent (i.e. last 6 months) shift (> 5%) in body mass or large change in habitual lifestyle
- •3. Individuals with coronary heart disease, chronic kidney disease, type 2 diabetes, stroke, heart failure and peripheral arterial disease
- •4. Individuals with ‘severe hypertension’ defined as a blood pressure greater than 180/110 mmHg (British Hypertension Society and NICE guidelines – CG127)
- •5. Individuals unable to change their physical activity (e.g. through disability)
- •6. Positive responses to the Physical Activity Readiness Questionnaire (PAR-Q)
- •7. Recent (i.e. last 2 months) participation in another research trial or lifestyle supportive intervention. (Participants will be asked not to donate blood whilst participating in the study)
- •8. Taking medication that might interfere with the study outcomes
- •9. Regular consumption of dietary supplements containing vitamin D
- •10. Regular use of sunbeds
- •11. Abnormal resting ECG (for arteriovenous difference participants, only)
- •12. Sensitivity or allergy to lidocaine or any local anaesthetic medicines.
- •13. Pregnancy
- •Group 2: Lean comparator group
- •1. Current or recent use of weight loss drugs
- •2. Any reported recent (i.e. last 6 months) shift (> 5%) in body mass or large change in habitual lifestyle
- •3. Individuals with coronary heart disease, chronic kidney disease, type 2 diabetes, stroke, heart failure and peripheral arterial disease
- •4. Individuals with ‘severe hypertension’ defined as a blood pressure greater than 180/110 mmHg (British Hypertension Society and NICE guidelines – CG127)
- •5. Positive responses to the Physical Activity Readiness Questionnaire (PAR-Q)
- •6. Recent (i.e. last 2 months) participation in another research trial or lifestyle supportive intervention. (Participants will be asked not to donate blood whilst participating in the study)
- •7. Taking medication that might interfere with the study outcomes
- •8. Regular consumption of dietary supplements containing vitamin D
- •9. Regular use of sunbeds
- •10. Abnormal resting ECG (for arteriovenous difference participants, only)
- •11. Sensitivity or allergy to lidocaine or any local anaesthetic medicines.
- •12. Pregnancy
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